Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

Lei Xing; Yue Li; Tonglei Li

doi:10.5731/pdajpst.2018.009357

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Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

Lei Xing, Yue Li and Tonglei Li

PDA Journal of Pharmaceutical Science and Technology May 2019, 73 (3) 260-275; DOI: https://doi.org/10.5731/pdajpst.2018.009357

Lei Xing

Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907

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Yue Li

Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907

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Tonglei Li

Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907

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For correspondence: tonglei@purdue.edu

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vol. 73 no. 3 260-275

DOI

https://doi.org/10.5731/pdajpst.2018.009357

PubMed

30651339

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Parenteral Drug Association (PDA)

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1079-7440

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1948-2124

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Published online May 31, 2019.

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previous version (January 16, 2019 - 07:46).
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Lei Xing,
Yue Li and
Tonglei Li*

Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907

↵* Corresponding Author: Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907; Telephone: +1 (765) 494-1451; e-mail: tonglei{at}purdue.edu

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Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

Lei Xing, Yue Li, Tonglei Li

PDA Journal of Pharmaceutical Science and Technology May 2019, 73 (3) 260-275; DOI: 10.5731/pdajpst.2018.009357

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Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

Lei Xing, Yue Li, Tonglei Li

PDA Journal of Pharmaceutical Science and Technology May 2019, 73 (3) 260-275; DOI: 10.5731/pdajpst.2018.009357

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Keywords

extensional flow
aggregation
unfolding
two-phase flow
Protein formulation
auto-injector

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Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

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