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Research ArticleResearch

Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model

Lei Xing, Yue Li and Tonglei Li
PDA Journal of Pharmaceutical Science and Technology May 2019, 73 (3) 260-275; DOI: https://doi.org/10.5731/pdajpst.2018.009357
Lei Xing
Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907
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Yue Li
Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907
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Tonglei Li
Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907
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  • For correspondence: tonglei@purdue.edu
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Article Information

vol. 73 no. 3 260-275
DOI 
https://doi.org/10.5731/pdajpst.2018.009357
PubMed 
30651339

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online May 31, 2019.

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  • previous version (January 16, 2019 - 07:46).
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© PDA, Inc. 2019

Author Information

  1. Lei Xing,
  2. Yue Li and
  3. Tonglei Li*
  1. Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907
  1. ↵* Corresponding Author: Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907; Telephone: +1 (765) 494-1451; e-mail: tonglei{at}purdue.edu
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PDA Journal of Pharmaceutical Science and Technology: 73 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 73, Issue 3
May/June 2019
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Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model
Lei Xing, Yue Li, Tonglei Li
PDA Journal of Pharmaceutical Science and Technology May 2019, 73 (3) 260-275; DOI: 10.5731/pdajpst.2018.009357

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Local Concentrating, Not Shear Stress, That May Lead to Possible Instability of Protein Molecules During Syringe Injection: A Fluid Dynamic Study with Two-Phase Flow Model
Lei Xing, Yue Li, Tonglei Li
PDA Journal of Pharmaceutical Science and Technology May 2019, 73 (3) 260-275; DOI: 10.5731/pdajpst.2018.009357
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    • Abstract
    • 1. Introduction
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  • Container Closure Integrity of Vial Primary Packaging Systems under Frozen Storage Conditions: A Case Study
  • Advances in Large Volume Subcutaneous Injections: A Pilot Tolerability Study of an Innovative Needle-Free Injection Platform
  • Quantification and Stability Impact Assessment of Drop Stresses in Biologic Drug Products
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Keywords

  • extensional flow
  • aggregation
  • unfolding
  • two-phase flow
  • Protein formulation
  • auto-injector

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