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Research ArticleResearch

Quantifying the Vial-Capping Process: Reexamination Using Micro-Computed Tomography

Robert Ovadia, Philippe Lam, Vassia Tegoulia and Yuh-Fun Maa
PDA Journal of Pharmaceutical Science and Technology March 2020, 74 (2) 171-184; DOI: https://doi.org/10.5731/pdajpst.2019.010363
Robert Ovadia
Pharmaceutical Processing and Technology Development, Genentech, A Member of the Roche Group, San Francisco, CA USA
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Philippe Lam
Pharmaceutical Processing and Technology Development, Genentech, A Member of the Roche Group, San Francisco, CA USA
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Vassia Tegoulia
Pharmaceutical Processing and Technology Development, Genentech, A Member of the Roche Group, San Francisco, CA USA
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Yuh-Fun Maa
Pharmaceutical Processing and Technology Development, Genentech, A Member of the Roche Group, San Francisco, CA USA
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  • For correspondence: maay@gene.com
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PDA Journal of Pharmaceutical Science and Technology: 74 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 74, Issue 2
March/April 2020
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Quantifying the Vial-Capping Process: Reexamination Using Micro-Computed Tomography
Robert Ovadia, Philippe Lam, Vassia Tegoulia, Yuh-Fun Maa
PDA Journal of Pharmaceutical Science and Technology Mar 2020, 74 (2) 171-184; DOI: 10.5731/pdajpst.2019.010363

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Quantifying the Vial-Capping Process: Reexamination Using Micro-Computed Tomography
Robert Ovadia, Philippe Lam, Vassia Tegoulia, Yuh-Fun Maa
PDA Journal of Pharmaceutical Science and Technology Mar 2020, 74 (2) 171-184; DOI: 10.5731/pdajpst.2019.010363
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Keywords

  • Micro-computed tomography
  • Micro-CT
  • Residual seal force
  • RSF
  • Vial capping
  • Container closure integrity
  • CCI
  • Primary packaging components
  • Helium leakage
  • Vial
  • Stopper
  • Crimp cap

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