A Vial Container Closure System Performance Optimization Case Study Using Comprehensive Dimensional Stack-Up Analyses

Anthony Bucci; Le Ho; Lauren Orme; Qingyu Zeng

doi:10.5731/pdajpst.2019.010843

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A Vial Container Closure System Performance Optimization Case Study Using Comprehensive Dimensional Stack-Up Analyses

Anthony Bucci, Le Ho, Lauren Orme and Qingyu Zeng

PDA Journal of Pharmaceutical Science and Technology July 2020, 74 (4) 368-376; DOI: https://doi.org/10.5731/pdajpst.2019.010843

Anthony Bucci

West Pharmaceutical Services, Inc.

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Le Ho

West Pharmaceutical Services, Inc.

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Lauren Orme

West Pharmaceutical Services, Inc.

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Qingyu Zeng

West Pharmaceutical Services, Inc.

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For correspondence: qingyu.zeng@westpharma.com

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vol. 74 no. 4 368-376

DOI

https://doi.org/10.5731/pdajpst.2019.010843

PubMed

32060224

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

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Published online July 31, 2020.

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previous version (February 14, 2020 - 07:26).
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Anthony Bucci,
Le Ho,
Lauren Orme and
Qingyu Zeng*

West Pharmaceutical Services, Inc.

↵*Corresponding Author: West Pharmaceutical Services, Inc., 530 Herman O. West Dr., Exton, PA 19341; E-mail: qingyu.zeng{at}westpharma.com

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A Vial Container Closure System Performance Optimization Case Study Using Comprehensive Dimensional Stack-Up Analyses

Anthony Bucci, Le Ho, Lauren Orme, Qingyu Zeng

PDA Journal of Pharmaceutical Science and Technology Jul 2020, 74 (4) 368-376; DOI: 10.5731/pdajpst.2019.010843

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A Vial Container Closure System Performance Optimization Case Study Using Comprehensive Dimensional Stack-Up Analyses

Anthony Bucci, Le Ho, Lauren Orme, Qingyu Zeng

PDA Journal of Pharmaceutical Science and Technology Jul 2020, 74 (4) 368-376; DOI: 10.5731/pdajpst.2019.010843

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Keywords

Container closure system (CCS)
Residual seal force (RSF)
Container closure integrity (CCI)
Stopper
Vial
Cap
Seal
Capping
Modeling
Performance Window
Dimensional Testing

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