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PDA Journal of Pharmaceutical Science and Technology

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Research ArticleResearch

Low-Volume Aseptic Filling Using a Linear Peristaltic Pump

Tim Dreckmann, Imke-Sonja Ludwig, JOERG LUEMKEMANN and JOERG Huwyler
PDA Journal of Pharmaceutical Science and Technology May 2021, 75 (3) 245-257; DOI: https://doi.org/10.5731/pdajpst.2020.011858
Tim Dreckmann
1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
2University of Basel, Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, 4056 Basel
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  • For correspondence: tim.dreckmann@roche.com
Imke-Sonja Ludwig
1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
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JOERG LUEMKEMANN
1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
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JOERG Huwyler
2University of Basel, Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, 4056 Basel
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Article Information

vol. 75 no. 3 245-257
DOI 
https://doi.org/10.5731/pdajpst.2020.011858
PubMed 
33067332

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online May 31, 2021.

Article Versions

  • previous version (October 16, 2020 - 09:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2021

Author Information

  1. Tim Dreckmann1,2,*,
  2. Imke-Sonja Ludwig1,
  3. JOERG LUEMKEMANN1 and
  4. JOERG Huwyler2
  1. 1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
  2. 2University of Basel, Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, 4056 Basel
  1. ↵* Corresponding Author: F. Hoffmann-La Roche Ltd, Drug Product Manufacturing Kaiseraugst, Bldg. 228 R. 1.10, 4303 Kaiseraugst, Switzerland; Telephone: +41 61 68 85143; E-mail: tim.dreckmann{at}roche.com
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PDA Journal of Pharmaceutical Science and Technology: 75 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 75, Issue 3
May/June 2021
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Low-Volume Aseptic Filling Using a Linear Peristaltic Pump
Tim Dreckmann, Imke-Sonja Ludwig, JOERG LUEMKEMANN, JOERG Huwyler
PDA Journal of Pharmaceutical Science and Technology May 2021, 75 (3) 245-257; DOI: 10.5731/pdajpst.2020.011858

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Low-Volume Aseptic Filling Using a Linear Peristaltic Pump
Tim Dreckmann, Imke-Sonja Ludwig, JOERG LUEMKEMANN, JOERG Huwyler
PDA Journal of Pharmaceutical Science and Technology May 2021, 75 (3) 245-257; DOI: 10.5731/pdajpst.2020.011858
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Jump to section

  • Article
    • Abstract
    • Introduction
    • Filling Systems
    • Piston Pump
    • Time-Pressure System
    • Radial Peristaltic Pump
    • Linear Peristaltic Pump
    • Aim of the Study
    • Materials and Methods
    • Filling System
    • Filling Accuracy Target
    • Filling Accuracy Readout
    • Results
    • Linear Peristaltic Pump: Filling Accuracy
    • Discussion
    • Conclusion
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

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Keywords

  • Low-volume filling
  • Microdosing
  • Proteins
  • Aseptic filling
  • Filling systems
  • Pumps
  • Single-use technology

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