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Research ArticleResearch

Low-Volume Aseptic Filling Using a Linear Peristaltic Pump

Tim Dreckmann, Imke-Sonja Ludwig, JOERG LUEMKEMANN and JOERG Huwyler
PDA Journal of Pharmaceutical Science and Technology May 2021, 75 (3) 245-257; DOI: https://doi.org/10.5731/pdajpst.2020.011858
Tim Dreckmann
1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
2University of Basel, Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, 4056 Basel
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  • For correspondence: tim.dreckmann@roche.com
Imke-Sonja Ludwig
1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
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JOERG LUEMKEMANN
1F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland; and
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JOERG Huwyler
2University of Basel, Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, 4056 Basel
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  • Article
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PDA Journal of Pharmaceutical Science and Technology: 75 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 75, Issue 3
May/June 2021
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Low-Volume Aseptic Filling Using a Linear Peristaltic Pump
Tim Dreckmann, Imke-Sonja Ludwig, JOERG LUEMKEMANN, JOERG Huwyler
PDA Journal of Pharmaceutical Science and Technology May 2021, 75 (3) 245-257; DOI: 10.5731/pdajpst.2020.011858

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Low-Volume Aseptic Filling Using a Linear Peristaltic Pump
Tim Dreckmann, Imke-Sonja Ludwig, JOERG LUEMKEMANN, JOERG Huwyler
PDA Journal of Pharmaceutical Science and Technology May 2021, 75 (3) 245-257; DOI: 10.5731/pdajpst.2020.011858
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  • Article
    • Abstract
    • Introduction
    • Filling Systems
    • Piston Pump
    • Time-Pressure System
    • Radial Peristaltic Pump
    • Linear Peristaltic Pump
    • Aim of the Study
    • Materials and Methods
    • Filling System
    • Filling Accuracy Target
    • Filling Accuracy Readout
    • Results
    • Linear Peristaltic Pump: Filling Accuracy
    • Discussion
    • Conclusion
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • Info & Metrics
  • References
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  • Advances in Large Volume Subcutaneous Injections: A Pilot Tolerability Study of an Innovative Needle-Free Injection Platform
  • Quantification and Stability Impact Assessment of Drop Stresses in Biologic Drug Products
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Keywords

  • Low-volume filling
  • Microdosing
  • Proteins
  • Aseptic filling
  • Filling systems
  • Pumps
  • Single-use technology

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