Physicochemical Excipient-Container Interactions in Prefilled Syringes and Their Impact on Syringe Functionality

Liang Fang; Coralie AdÈle Richard; Galen Huaiqiu Shi; Xia Dong; Marissa Rase; Tingting Wang

doi:10.5731/pdajpst.2020.012278

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Physicochemical Excipient-Container Interactions in Prefilled Syringes and Their Impact on Syringe Functionality

Liang Fang, Coralie AdÈle Richard, Galen Huaiqiu Shi, Xia Dong, Marissa Rase and Tingting Wang

PDA Journal of Pharmaceutical Science and Technology July 2021, 75 (4) 317-331; DOI: https://doi.org/10.5731/pdajpst.2020.012278

Liang Fang

1West Pharmaceutical Services, Inc., Exton, PA; and

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Coralie AdÈle Richard

2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN

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Galen Huaiqiu Shi

2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN

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Xia Dong

2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN

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Marissa Rase

1West Pharmaceutical Services, Inc., Exton, PA; and

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Tingting Wang

2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN

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For correspondence: wang_tingting@lilly.com

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vol. 75 no. 4 317-331

DOI

https://doi.org/10.5731/pdajpst.2020.012278

PubMed

33452050

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online August 3, 2021.

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previous version (January 15, 2021 - 10:29).
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Author Information

Liang Fang¹,
Coralie AdÈle Richard²,
Galen Huaiqiu Shi²,
Xia Dong²,
Marissa Rase¹ and
Tingting Wang²,*

¹West Pharmaceutical Services, Inc., Exton, PA; and
²Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN

↵* Corresponding Author: Lilly Corporate Center, Indianapolis, IN 46265; Telephone: 317-277-4041; E-mail: wang_tingting{at}lilly.com

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Physicochemical Excipient-Container Interactions in Prefilled Syringes and Their Impact on Syringe Functionality

Liang Fang, Coralie AdÈle Richard, Galen Huaiqiu Shi, Xia Dong, Marissa Rase, Tingting Wang

PDA Journal of Pharmaceutical Science and Technology Jul 2021, 75 (4) 317-331; DOI: 10.5731/pdajpst.2020.012278

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Physicochemical Excipient-Container Interactions in Prefilled Syringes and Their Impact on Syringe Functionality

Liang Fang, Coralie AdÈle Richard, Galen Huaiqiu Shi, Xia Dong, Marissa Rase, Tingting Wang

PDA Journal of Pharmaceutical Science and Technology Jul 2021, 75 (4) 317-331; DOI: 10.5731/pdajpst.2020.012278

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Keywords

prefilled syringe
Autoinjector
Glide force
Silicone oil
Surfactant
Polysorbate
Poloxamer
Hansen solubility parameters

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