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Research ArticleResearch

A New Integrated Modeling Approach with Case Studies for Gas Transmission of Container Closure Headspace

Qingyu Zeng
PDA Journal of Pharmaceutical Science and Technology September 2021, 75 (5) 394-406; DOI: https://doi.org/10.5731/pdajpst.2020.012351
Qingyu Zeng
West Pharmaceutical Services, Inc.
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  • For correspondence: qingyu.zeng@westpharma.com
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Article Information

vol. 75 no. 5 394-406
DOI 
https://doi.org/10.5731/pdajpst.2020.012351
PubMed 
33858948

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online September 27, 2021.

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  • previous version (April 15, 2021 - 10:30).
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© PDA, Inc. 2021

Author Information

  1. Qingyu Zeng⇑
  1. West Pharmaceutical Services, Inc.
  1. *Corresponding Author: West Pharmaceutical Services, Inc., 530 Herman O. West Dr., Exton, PA 19341; E-mail: qingyu.zeng{at}westpharma.com
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PDA Journal of Pharmaceutical Science and Technology: 75 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 75, Issue 5
September/October 2021
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A New Integrated Modeling Approach with Case Studies for Gas Transmission of Container Closure Headspace
Qingyu Zeng
PDA Journal of Pharmaceutical Science and Technology Sep 2021, 75 (5) 394-406; DOI: 10.5731/pdajpst.2020.012351

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A New Integrated Modeling Approach with Case Studies for Gas Transmission of Container Closure Headspace
Qingyu Zeng
PDA Journal of Pharmaceutical Science and Technology Sep 2021, 75 (5) 394-406; DOI: 10.5731/pdajpst.2020.012351
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    • Abstract
    • Introduction
    • Methods—Formulation of the Integrated Modeling Framework
    • Results and Discussion
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  • A Container Closure Integrity Test Method for Vials Stored at Cryogenic Conditions Using Headspace Oxygen Analysis
  • Container Closure Integrity Test Method Development on Vials Stored at -80{degrees}C Using Headspace Carbon Dioxide Analysis
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Keywords

  • Container closure system (CCS)
  • Container closure integrity (CCI)
  • Diffusion
  • Mass and volumetric flow
  • Fick's law
  • Darcy–Weisbach equation

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