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Research ArticleResearch

Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal

Brad Stanley, Veronica Holmes, Richard Manzari, Cara Romanowski, Anja Tessarz, Horst Ruppach and John Schreffler
PDA Journal of Pharmaceutical Science and Technology January 2022, 76 (1) 1-8; DOI: https://doi.org/10.5731/pdajpst.2020.012591
Brad Stanley
1Biogen, Inc., Process Biochemistry, 5000 Davis Drive, Research Triangle Park, NC;
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Veronica Holmes
2Janssen R&D LLC, Biotherapeutic Development API, 200 Great Valley Parkway, Malvern, PA;
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Richard Manzari
3WuXi Advanced Therapies, Viral Clearance, 4751 League Island Boulevard, Philadelphia, PA; and
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Cara Romanowski
3WuXi Advanced Therapies, Viral Clearance, 4751 League Island Boulevard, Philadelphia, PA; and
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Anja Tessarz
4Charles River Laboratories Germany GmbH, Biologics Testing, Gottfried-Hagen Strasse 20, 51105 Köln, Germany
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Horst Ruppach
4Charles River Laboratories Germany GmbH, Biologics Testing, Gottfried-Hagen Strasse 20, 51105 Köln, Germany
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John Schreffler
2Janssen R&D LLC, Biotherapeutic Development API, 200 Great Valley Parkway, Malvern, PA;
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  • For correspondence: jschreff@its.jnj.com
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Article Information

vol. 76 no. 1 1-8
DOI 
https://doi.org/10.5731/pdajpst.2020.012591
PubMed 
33990425

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online February 1, 2022.

Article Versions

  • previous version (May 14, 2021 - 13:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2022

Author Information

  1. Brad Stanley1,
  2. Veronica Holmes2,
  3. Richard Manzari3,
  4. Cara Romanowski3,
  5. Anja Tessarz4,
  6. Horst Ruppach4 and
  7. John Schreffler2,*
  1. 1Biogen, Inc., Process Biochemistry, 5000 Davis Drive, Research Triangle Park, NC;
  2. 2Janssen R&D LLC, Biotherapeutic Development API, 200 Great Valley Parkway, Malvern, PA;
  3. 3WuXi Advanced Therapies, Viral Clearance, 4751 League Island Boulevard, Philadelphia, PA; and
  4. 4Charles River Laboratories Germany GmbH, Biologics Testing, Gottfried-Hagen Strasse 20, 51105 Köln, Germany
  1. ↵*Corresponding Author: 200 Great Valley Parkway, Malvern, PA 19355; Telephone: 570-436-8047; E-mail: jschreff{at}its.jnj.com
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PDA Journal of Pharmaceutical Science and Technology: 76 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 76, Issue 1
January/February 2022
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Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal
Brad Stanley, Veronica Holmes, Richard Manzari, Cara Romanowski, Anja Tessarz, Horst Ruppach, John Schreffler
PDA Journal of Pharmaceutical Science and Technology Jan 2022, 76 (1) 1-8; DOI: 10.5731/pdajpst.2020.012591

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Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal
Brad Stanley, Veronica Holmes, Richard Manzari, Cara Romanowski, Anja Tessarz, Horst Ruppach, John Schreffler
PDA Journal of Pharmaceutical Science and Technology Jan 2022, 76 (1) 1-8; DOI: 10.5731/pdajpst.2020.012591
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Keywords

  • Virus filtration
  • Modular viral clearance
  • Small virus retentive filter
  • Large virus retentive filter
  • Viral clearance
  • Murine leukemia virus (MuLV)
  • Reovirus (Reo-3)
  • Pseudorabies virus (PrV)

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