Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal

Brad Stanley; Veronica Holmes; Richard Manzari; Cara Romanowski; Anja Tessarz; Horst Ruppach; John Schreffler

doi:10.5731/pdajpst.2020.012591

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Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal

Brad Stanley, Veronica Holmes, Richard Manzari, Cara Romanowski, Anja Tessarz, Horst Ruppach and John Schreffler

PDA Journal of Pharmaceutical Science and Technology January 2022, 76 (1) 1-8; DOI: https://doi.org/10.5731/pdajpst.2020.012591

Brad Stanley

1Biogen, Inc., Process Biochemistry, 5000 Davis Drive, Research Triangle Park, NC;

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Veronica Holmes

2Janssen R&D LLC, Biotherapeutic Development API, 200 Great Valley Parkway, Malvern, PA;

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Richard Manzari

3WuXi Advanced Therapies, Viral Clearance, 4751 League Island Boulevard, Philadelphia, PA; and

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Cara Romanowski

3WuXi Advanced Therapies, Viral Clearance, 4751 League Island Boulevard, Philadelphia, PA; and

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Anja Tessarz

4Charles River Laboratories Germany GmbH, Biologics Testing, Gottfried-Hagen Strasse 20, 51105 Köln, Germany

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Horst Ruppach

4Charles River Laboratories Germany GmbH, Biologics Testing, Gottfried-Hagen Strasse 20, 51105 Köln, Germany

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John Schreffler

2Janssen R&D LLC, Biotherapeutic Development API, 200 Great Valley Parkway, Malvern, PA;

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For correspondence: jschreff@its.jnj.com

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vol. 76 no. 1 1-8

DOI

https://doi.org/10.5731/pdajpst.2020.012591

PubMed

33990425

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

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Published online February 1, 2022.

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previous version (May 14, 2021 - 13:18).
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Author Information

Brad Stanley¹,
Veronica Holmes²,
Richard Manzari³,
Cara Romanowski³,
Anja Tessarz⁴,
Horst Ruppach⁴ and
John Schreffler²,*

¹Biogen, Inc., Process Biochemistry, 5000 Davis Drive, Research Triangle Park, NC;
²Janssen R&D LLC, Biotherapeutic Development API, 200 Great Valley Parkway, Malvern, PA;
³WuXi Advanced Therapies, Viral Clearance, 4751 League Island Boulevard, Philadelphia, PA; and
⁴Charles River Laboratories Germany GmbH, Biologics Testing, Gottfried-Hagen Strasse 20, 51105 Köln, Germany

↵*Corresponding Author: 200 Great Valley Parkway, Malvern, PA 19355; Telephone: 570-436-8047; E-mail: jschreff{at}its.jnj.com

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Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal

Brad Stanley, Veronica Holmes, Richard Manzari, Cara Romanowski, Anja Tessarz, Horst Ruppach, John Schreffler

PDA Journal of Pharmaceutical Science and Technology Jan 2022, 76 (1) 1-8; DOI: 10.5731/pdajpst.2020.012591

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Twenty plus Years of Data Demonstrating Virus Filtration as an Effective and Robust Step for Large Virus Removal

Brad Stanley, Veronica Holmes, Richard Manzari, Cara Romanowski, Anja Tessarz, Horst Ruppach, John Schreffler

PDA Journal of Pharmaceutical Science and Technology Jan 2022, 76 (1) 1-8; DOI: 10.5731/pdajpst.2020.012591

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Keywords

Virus filtration
Modular viral clearance
Small virus retentive filter
Large virus retentive filter
Viral clearance
Murine leukemia virus (MuLV)
Reovirus (Reo-3)
Pseudorabies virus (PrV)

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