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Research ArticleResearch

Mechanistic Study of Drying Phenomena of Highly Concentrated Protein Therapeutics—Drying Kinetics and Protein Aggregation

Andrea Allmendinger, Yuan Ni, Alexander Bernhard and Heiko Nalenz
PDA Journal of Pharmaceutical Science and Technology January 2022, 76 (1) 52-64; DOI: https://doi.org/10.5731/pdajpst.2020.012492
Andrea Allmendinger
aPharmaceutical Development & Supplies Biologics EU, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland;
bDepartment of Pharmaceutical Technology and Biopharmacy, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Hermann-Herder-Str. 9, 79104 Freiburg, Germany
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  • For correspondence: allmendingerandrea@gmail.com
Yuan Ni
aPharmaceutical Development & Supplies Biologics EU, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland;
bDepartment of Pharmaceutical Technology and Biopharmacy, Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Hermann-Herder-Str. 9, 79104 Freiburg, Germany
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Alexander Bernhard
aPharmaceutical Development & Supplies Biologics EU, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland;
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Heiko Nalenz
aPharmaceutical Development & Supplies Biologics EU, F. Hoffmann-La Roche, Grenzacherstrasse 124, 4070 Basel, Switzerland;
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PDA Journal of Pharmaceutical Science and Technology: 76 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 76, Issue 1
January/February 2022
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Mechanistic Study of Drying Phenomena of Highly Concentrated Protein Therapeutics—Drying Kinetics and Protein Aggregation
Andrea Allmendinger, Yuan Ni, Alexander Bernhard, Heiko Nalenz
PDA Journal of Pharmaceutical Science and Technology Jan 2022, 76 (1) 52-64; DOI: 10.5731/pdajpst.2020.012492

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Mechanistic Study of Drying Phenomena of Highly Concentrated Protein Therapeutics—Drying Kinetics and Protein Aggregation
Andrea Allmendinger, Yuan Ni, Alexander Bernhard, Heiko Nalenz
PDA Journal of Pharmaceutical Science and Technology Jan 2022, 76 (1) 52-64; DOI: 10.5731/pdajpst.2020.012492
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Keywords

  • monoclonal antibody
  • highly concentrated protein formulation
  • Aseptic filling
  • drying events
  • nozzle clogging
  • fill-finish

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