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PDA Journal of Pharmaceutical Science and Technology

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Research ArticleTechnology/Application

Microbial Contamination in Water Systems

Fritz Röder and Tim Sandle
PDA Journal of Pharmaceutical Science and Technology September 2022, 76 (5) 434-443; DOI: https://doi.org/10.5731/pdajpst.2021.012636
Fritz Röder
1Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany; and
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  • For correspondence: Fritz.roeder@merckgroup.com
Tim Sandle
2Bio Products Laboratory Limited, Dagger Lane, Elstree Herts, WD6 3BX U.K.
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Article Information

vol. 76 no. 5 434-443
DOI 
https://doi.org/10.5731/pdajpst.2021.012636
PubMed 
35169037

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online October 3, 2022.

Article Versions

  • previous version (February 15, 2022 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2022

Author Information

  1. Fritz Röder1,* and
  2. Tim Sandle2
  1. 1Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany; and
  2. 2Bio Products Laboratory Limited, Dagger Lane, Elstree Herts, WD6 3BX U.K.
  1. ↵*Corresponding Author: Merck Healthcare KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany; Telephone: +49/6151/72-57929; E-mail: Fritz.roeder{at}merckgroup.com
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PDA Journal of Pharmaceutical Science and Technology: 76 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 76, Issue 5
September/October 2022
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Microbial Contamination in Water Systems
Fritz Röder, Tim Sandle
PDA Journal of Pharmaceutical Science and Technology Sep 2022, 76 (5) 434-443; DOI: 10.5731/pdajpst.2021.012636

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Microbial Contamination in Water Systems
Fritz Röder, Tim Sandle
PDA Journal of Pharmaceutical Science and Technology Sep 2022, 76 (5) 434-443; DOI: 10.5731/pdajpst.2021.012636
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Jump to section

  • Article
    • Abstract
    • Microbial Ecology of Pharmaceutical Water Systems
    • Antimicrobial Water Treatment
    • Ozone
    • Chlorine
    • Chloramines
    • UV Light
    • Heat
    • Protective Mechanisms
    • Implementation of a Sanitization Concept for a Water System
    • Reliable Operation of Water Systems
    • In Case of Microbial Proliferation inside the System
    • Summary
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
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  • Best Practices for Microbial Challenge In-Use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations
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Keywords

  • Water
  • sanitization
  • GMP
  • Biofilm
  • Microbiology
  • Purified water
  • water for injection

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