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Research ArticleResearch

Measurement of Solution Composition as an Alternative to Titration for Evaluating the Hydrolytic Resistance of Glass

Susan L. Schiefelbein, K. Deenamma Vargheese, Robert A. Schaut, Ela Bakowska, Misty N. Riesbeck, Daniel D. Kramer and William H. Stull
PDA Journal of Pharmaceutical Science and Technology November 2023, 77 (6) 437-448; DOI: https://doi.org/10.5731/pdajpst.2022.012737
Susan L. Schiefelbein
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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  • For correspondence: schiefelsl@corning.com
K. Deenamma Vargheese
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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Robert A. Schaut
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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Ela Bakowska
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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Misty N. Riesbeck
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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Daniel D. Kramer
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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William H. Stull
Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
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Article Information

vol. 77 no. 6 437-448
DOI 
https://doi.org/10.5731/pdajpst.2022.012737
PubMed 
37321862

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 7, 2023.

Article Versions

  • previous version (June 15, 2023 - 12:15).
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Copyright & Usage 
© PDA, Inc. 2023

Author Information

  1. Susan L. Schiefelbein*,
  2. K. Deenamma Vargheese,
  3. Robert A. Schaut,
  4. Ela Bakowska,
  5. Misty N. Riesbeck,
  6. Daniel D. Kramer and
  7. William H. Stull
  1. Sullivan Park Science & Technology Center, Corning Incorporated, Erwin, NY 14870
  1. ↵* Corresponding Author: Corning Incorporated, Sullivan Park Science & Technology Center, 1 Science Center Rd., Erwin, NY, 14870; Telephone: (607) 974-6646; E-mail: schiefelsl{at}corning.com
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PDA Journal of Pharmaceutical Science and Technology: 77 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 77, Issue 6
November/December 2023
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Measurement of Solution Composition as an Alternative to Titration for Evaluating the Hydrolytic Resistance of Glass
Susan L. Schiefelbein, K. Deenamma Vargheese, Robert A. Schaut, Ela Bakowska, Misty N. Riesbeck, Daniel D. Kramer, William H. Stull
PDA Journal of Pharmaceutical Science and Technology Nov 2023, 77 (6) 437-448; DOI: 10.5731/pdajpst.2022.012737

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Measurement of Solution Composition as an Alternative to Titration for Evaluating the Hydrolytic Resistance of Glass
Susan L. Schiefelbein, K. Deenamma Vargheese, Robert A. Schaut, Ela Bakowska, Misty N. Riesbeck, Daniel D. Kramer, William H. Stull
PDA Journal of Pharmaceutical Science and Technology Nov 2023, 77 (6) 437-448; DOI: 10.5731/pdajpst.2022.012737
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Keywords

  • Thermodynamics
  • Speciation
  • pH
  • Titration volume
  • Alkalinity
  • Hydrolytic resistance
  • ICP-MS

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