Stopper Movement and Headspace (Air Bubble Size) Limitations for 2.25 mL Prefilled Syringe

References

1. 1.↵
   1. Zhao J.,
   2. Lavalley V.,
   3. Mangiagalli P.,
   4. Wright J. M.,
   5. Bankston T. E.

   Glass Delamination: A Comparison of the Inner Surface Performance of Vials and Pre-Filled Syringes. AAPS PharmSciTech 2014, 15 (6), 1398–1409.

   OpenUrlGoogle Scholar
2. 2.↵
   1. Sacha G.,
   2. Rogers J. A.,
   3. Miller R. L.

   Pre-Filled Syringes: A Review of the History, Manufacturing and Challenges. Pharm. Dev. Technol. 2015, 20 (1), 1–11.

   OpenUrlGoogle Scholar
3. 3.↵
   1. Zeiss B.

   Syringe Study – Gerresheimer – Scrutinizing 20,000 Syringes, a Long-Term Study (2011-2015). Drug Dev. Delivery. 2015, 15. https://drug-dev.com/syringe-study-gerresheimer-scrutinizing-20000-syringes-a-long-term-study-2011-2015/.

   Google Scholar
4. 4.↵
   1. Stauffer O.,
   2. Wolf H.

   Defining the Sterile Barrier of Complex Drug Delivery Systems. BioPharm Int. 2014. https://www.biopharminternational.com/view/defining-sterile-barrier-complex-drug-delivery-systems-0.

   Google Scholar
5. 5.↵
   1. Stauffer O.,
   2. Wolf H.

   Evaluating the Sterile Barrier of Complex Drug Delivery Systems. PharmTech 2014. https://www.pharmtech.com/view/evaluating-sterile-barrier-complex-drug-delivery-systems.

   Google Scholar
6. 6.↵
   1. Lorenz B.,
   2. Krick B. A.,
   3. Rodriguez N.,
   4. Sawyer W. G.,
   5. Mangiagalli P.,
   6. Persson B. N. J.

   Static or Breakloose Friction for Lubricated Contacts: The Role of Surface Roughness and Dewetting. J. Phys.: Condens. Matter 2013, 25 (44), 445013.

   OpenUrlCrossRefPubMedGoogle Scholar
7. 7.↵
   1. Berry C.,
   2. Kelly M.

   Plunger Stopper Movement Under Low Pressure. https://www.smithers.com/resources/2021/jan/plunger-stopper-movement-under-low-pressure.

   Google Scholar
8. 8.↵
   1. Chan E.,
   2. Maa Y.,
   3. Overcashier D.

   Manufacturing Consideration in Developing a Prefilled Syringe – Investigating the Effect of Headspace Pressure. Am. Pharm. Rev. 2012, 15 (3).

   Google Scholar
9. 9.↵
   1. Welch B.

   Critical Considerations in Choosing High Viscosity/High Volume Drug Delivery Devices. ONdrugDelivery 2018, (83), 50–53.

   Google Scholar
10. 10.↵
    1. Wagner A.

    Advances in Prefilled Syringe Technology. https://s3-us-west-1.amazonaws.com/ptab-filings%2FIPR2020-01317%2F2025.

    Google Scholar
11. 11.↵
    1. Kent M.

    The Oxford Dictionary of Sports Science & Medicine, 3rd ed; Oxford University Press, 2006.

    Google Scholar
12. 12.↵
    1. Blancher M.,
    2. Repellin M.,
    3. Maignan M.,
    4. Clapé C.,
    5. Perrin A.,
    6. Labarère J.,
    7. Debaty G.,
    8. Viglino D.

    Accuracy of Low-Weight versus Standard Syringe Infusion Pump Devices Depending on Altitude. Scand. J. Trauma Resusc. Emerg. Med. 2019, 27 (1), 65

    OpenUrlGoogle Scholar
13. 13.↵
    1. Nave R.

    The Barometric formula. http://hyperphysics.phy-astr.gsu.edu/hbase/Kinetic/barfor.html

    Google Scholar
14. 14.↵
    1. Singh S. P.,
    2. Singh J.,
    3. Stallings J.,
    4. Burgess G.,
    5. Saha K.

    Measurement and Analysis of Temperature and Pressure in High Altitude Air Shipments. Packag. Technol. Sci. 2010, 23 (1), 35–46.

    OpenUrlGoogle Scholar