Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleConference Proceedings

Proceedings of the 2023 Viral Clearance Symposium, Session 7: Up- and Downstream Virus Retentive Filtration

Xiaoxiang Zhu and Sean O’Donnell
PDA Journal of Pharmaceutical Science and Technology March 2024, 78 (2) 196-205; DOI: https://doi.org/10.5731/pdajpst.2024.002247
Xiaoxiang Zhu
1Pivotal Drug Substance Biologics, Process Development, Amgen Inc., 360 Binney Street, Cambridge, MA 02138; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sean O’Donnell
2BioProcess Research and Development, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: odonnell_sean_michael@lilly.com
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Wieser A.,
    2. Modrof J.,
    3. Kreil T. R.
    Protection of Biomanufacturing Processes from Virus Contamination through Upstream Virus Filtration of Cell Culture Media. Biotechnol. Bioeng. 2023, 120 (10), 2917–2924.
    OpenUrl
  2. 2.↵
    Parenteral Drug Association Inc. Technical Report No. 41 Revised: Virus Filtration; Bethesda, MD, 2022.
  3. 3.↵
    1. Grillberger L.,
    2. Kreil T. R.,
    3. Nasr S.,
    4. Reiter M.
    Emerging Trends in Plasma‐Free Manufacturing of Recombinant Protein Therapeutics Expressed in Mammalian Cells. Biotechnol. J. 2009, 4 (2), 186–201.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Garnick R. L.
    Raw Materials as a Source of Contamination in Large-Scale Cell Culture. Dev. Biol. Stand. 1998, 93, 21–29.
    OpenUrlPubMedWeb of Science
  5. 5.↵
    1. Nims R. W.
    Detection of Adventitious Viruses in Biologicals—A Rare Occurrence. Dev. Biol. (Basel, Switz.) 2006, 123 153–164. 2006,
    OpenUrl
  6. 6.↵
    The European Agency for the Evaluation of Medicinal Products, Human Medicines Evaluation Unit, CPMP Biotechnology Working Party. Note for Guidance on Virus Validation Studies: The Design, Contribution, and Interpretation of Studies Validating the Inactivation and Removal of Viruses; EMEA/CPMP/BWP/268/95; London, 1996.
  7. 7.↵
    1. Wieser A.,
    2. Berting A.,
    3. Medek C.,
    4. Poelsler G.,
    5. Kreil T. R.
    The Evolution of Down‐Scale Virus Filtration Equipment for Virus Clearance Studies. Biotechnol. Bioeng. 2015, 112 (3), 633–637.
    OpenUrl
  8. 8.↵
    1. Opeyemi O. A.,
    2. Johnson S. A.,
    3. Faison T.,
    4. Azer N.,
    5. Cullinan J. L.,
    6. Dement‐Brown J.,
    7. Lute S. C.
    An Updated Analysis of Viral Clearance Unit Operations for Biotechnology Manufacturing. Curr. Res. Biotechnol. 2022, 4, 190–202. 2022,
    OpenUrl
  9. 9.↵
    1. Yamamoto A.,
    2. Hongo-Hirasaki T.,
    3. Uchi Y.,
    4. Hayashida H.,
    5. Nagoya F.
    Effect of Hydrodynamic Forces on Virus Removal Capability of Planova™ Filters. “ AIChE J. 2014, 60 (6), 2286–2297.
    OpenUrl
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 78 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 78, Issue 2
March/April 2024
  • Table of Contents
  • Index by Author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Proceedings of the 2023 Viral Clearance Symposium, Session 7: Up- and Downstream Virus Retentive Filtration
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
4 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Proceedings of the 2023 Viral Clearance Symposium, Session 7: Up- and Downstream Virus Retentive Filtration
Xiaoxiang Zhu, Sean O’Donnell
PDA Journal of Pharmaceutical Science and Technology Mar 2024, 78 (2) 196-205; DOI: 10.5731/pdajpst.2024.002247

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Proceedings of the 2023 Viral Clearance Symposium, Session 7: Up- and Downstream Virus Retentive Filtration
Xiaoxiang Zhu, Sean O’Donnell
PDA Journal of Pharmaceutical Science and Technology Mar 2024, 78 (2) 196-205; DOI: 10.5731/pdajpst.2024.002247
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Background and Session Overview
    • Participant Contributions
    • Summary and Discussion
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Proceedings of the 2023 Viral Clearance Symposium, Session 1: Regulatory Updates
  • Proceedings of the 2023 Viral Clearance Symposium, Session 4: Continuous Processing
Show more Conference Proceedings

Similar Articles

Keywords

  • Virus filtration
  • Cell culture media
  • Pressure/flow interruptions
  • Viral filter cycling
  • Continuous/connected process
  • Viral filter reuse

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire