Impact of NaCl on Monoclonal Antibody Aggregation Induced by Agitation

Justin K.Y. Hong; Wei Liu; Kai Zheng

doi:10.5731/pdajpst.2023.012860

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Impact of NaCl on Monoclonal Antibody Aggregation Induced by Agitation

Justin K.Y. Hong, Wei Liu and Kai Zheng

PDA Journal of Pharmaceutical Science and Technology July 2024, 78 (4) 465-474; DOI: https://doi.org/10.5731/pdajpst.2023.012860

Justin K.Y. Hong

1Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080

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Wei Liu

1Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080

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Kai Zheng

1Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080

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For correspondence: kaizheng07@gmail.com

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vol. 78 no. 4 465-474

DOI

https://doi.org/10.5731/pdajpst.2023.012860

PubMed

39179400

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Parenteral Drug Association (PDA)

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1079-7440

Online ISSN

1948-2124

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Published online August 23, 2024.

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previous version (January 30, 2024 - 11:01).
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Justin K.Y. Hong^1,^a,
Wei Liu¹ and
Kai Zheng^1,^b,*

¹Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080

↵* Corresponding Author: Pharmaceutical Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; E-mail: kaizheng07{at}gmail.com

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Impact of NaCl on Monoclonal Antibody Aggregation Induced by Agitation

Justin K.Y. Hong, Wei Liu, Kai Zheng

PDA Journal of Pharmaceutical Science and Technology Jul 2024, 78 (4) 465-474; DOI: 10.5731/pdajpst.2023.012860

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Impact of NaCl on Monoclonal Antibody Aggregation Induced by Agitation

Justin K.Y. Hong, Wei Liu, Kai Zheng

PDA Journal of Pharmaceutical Science and Technology Jul 2024, 78 (4) 465-474; DOI: 10.5731/pdajpst.2023.012860

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Keywords

air-liquid interface
agitation stress
monoclonal antibody
pharmaceutical development
protein aggregation

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