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Research ArticleResearch

Coring and Fragmentation of Elastomeric Needle Shield in a Pre-Filled Syringe

Sahab Babaee, Sean Teller, Kavin Kowsari, Nikolaos Vasios, Steven C. Persak, Nagi Elabbasi and Guangli Hu
PDA Journal of Pharmaceutical Science and Technology May 2025, 79 (3) 274-284; DOI: https://doi.org/10.5731/pdajpst.2024-003041.1
Sahab Babaee
1Device Development & Technology, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065; and
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Sean Teller
2Veryst Engineering LLC, Needham, MA 02494
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Kavin Kowsari
1Device Development & Technology, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065; and
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Nikolaos Vasios
2Veryst Engineering LLC, Needham, MA 02494
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Steven C. Persak
1Device Development & Technology, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065; and
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Nagi Elabbasi
2Veryst Engineering LLC, Needham, MA 02494
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Guangli Hu
1Device Development & Technology, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065; and
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  • For correspondence: guangli.hu@merck.com
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References

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    1. Wani T.,
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    The Incidence of Propofol Vial Coring with Blunt Needle Use is Reduced with Angled Puncture Compared with Perpendicular Puncture. Anesth. Analg. 2015, 120 (4), 954–955.
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    Principles and Practice of Intravenous Therapy. AJN, Am. J. Nurs. 1976, 76 (1), 85.
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    1. Riess M. L.
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    1. Kohli N.,
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    Occurrence of Coring in Insulin Vials and Possibility of Rubber Piece Contamination by Self-Injection. Yakugaku Zasshi 2001, 121 (6), 459–463.
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    1. Sakai O.,
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    Cut-off Fragments of Rubber Caps of Bottles of Contrast Material: foreign Bodies in the Drip Infusion System. AJNR Am. J. Neuroradiol. 1996, 17 (6), 1194–1195.
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  15. 15.↵
    Abaqus User’s Manual. Dassault Systèmes: Johnston, RI, 2020.
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PDA Journal of Pharmaceutical Science and Technology: 79 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 3
May/June 2025
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Coring and Fragmentation of Elastomeric Needle Shield in a Pre-Filled Syringe
Sahab Babaee, Sean Teller, Kavin Kowsari, Nikolaos Vasios, Steven C. Persak, Nagi Elabbasi, Guangli Hu
PDA Journal of Pharmaceutical Science and Technology May 2025, 79 (3) 274-284; DOI: 10.5731/pdajpst.2024-003041.1

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Coring and Fragmentation of Elastomeric Needle Shield in a Pre-Filled Syringe
Sahab Babaee, Sean Teller, Kavin Kowsari, Nikolaos Vasios, Steven C. Persak, Nagi Elabbasi, Guangli Hu
PDA Journal of Pharmaceutical Science and Technology May 2025, 79 (3) 274-284; DOI: 10.5731/pdajpst.2024-003041.1
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Keywords

  • prefilled syringe
  • rigid needle shield
  • coring
  • elastomer material
  • numerical modeling

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