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Sealing behavior of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers

Alejandra Nieto and Holger Roehl
PDA Journal of Pharmaceutical Science and Technology March 2018, pdajpst.2017.008391; DOI: https://doi.org/10.5731/pdajpst.2017.008391
Alejandra Nieto
1 F. Hoffmann- La Roche Ltd.;
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  • For correspondence: alejandra.nieto@roche.com
Holger Roehl
2 F. Hoffmann - La Roche Ltd.
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  • For correspondence: holger.roehl@roche.com
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Article Information

pdajpst.2017.008391
DOI 
https://doi.org/10.5731/pdajpst.2017.008391
PubMed 
29545324

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Received October 13, 2017
  • Accepted March 8, 2018
  • Published online March 15, 2018.

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  • You are currently viewing a previous version of this article (March 15, 2018 - 18:21).
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Copyright & Usage 
Copyright © 2018, Parenteral Drug Association

Author Information

  1. Alejandra Nieto1,3 (alejandra.nieto{at}roche.com) and
  2. Holger Roehl2 (holger.roehl{at}roche.com)
  1. 1 F. Hoffmann- La Roche Ltd.;
  2. 2 F. Hoffmann - La Roche Ltd.
  1. ↵* Corresponding author; email: alejandra.nieto{at}roche.com

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PDA Journal of Pharmaceutical Science and Technology: 79 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 2
March/April 2025
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Sealing behavior of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers
Alejandra Nieto, Holger Roehl
PDA Journal of Pharmaceutical Science and Technology Mar 2018, pdajpst.2017.008391; DOI: 10.5731/pdajpst.2017.008391

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Sealing behavior of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers
Alejandra Nieto, Holger Roehl
PDA Journal of Pharmaceutical Science and Technology Mar 2018, pdajpst.2017.008391; DOI: 10.5731/pdajpst.2017.008391
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Keywords

  • Container closure integrity
  • Container closure system
  • Finite element analysis
  • Frozen drug product
  • parenteral primary packaging
  • Vial

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