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Sealing behavior of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers

Alejandra Nieto and Holger Roehl
PDA Journal of Pharmaceutical Science and Technology March 2018, pdajpst.2017.008391; DOI: https://doi.org/10.5731/pdajpst.2017.008391
Alejandra Nieto
1 F. Hoffmann- La Roche Ltd.;
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  • For correspondence: alejandra.nieto@roche.com
Holger Roehl
2 F. Hoffmann - La Roche Ltd.
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  • For correspondence: holger.roehl@roche.com
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PDA Journal of Pharmaceutical Science and Technology: 79 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 3
May/June 2025
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Sealing behavior of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers
Alejandra Nieto, Holger Roehl
PDA Journal of Pharmaceutical Science and Technology Mar 2018, pdajpst.2017.008391; DOI: 10.5731/pdajpst.2017.008391
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  • Quantifying the Vial-Capping Process: Reexamination Using Micro-Computed Tomography
  • Evaluation of Container Closure System Integrity for Storage of Frozen Drug Products: Impact of Capping Force and Transportation
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  • Coring and Fragmentation of Elastomeric Needle Shield in a Pre-Filled Syringe
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Keywords

  • Container closure integrity
  • Container closure system
  • Finite element analysis
  • Frozen drug product
  • parenteral primary packaging
  • Vial

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© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

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Sealing behavior of Container Closure Systems under Frozen Storage Conditions: Nonlinear Finite Element Simulation of Serum Rubber Stoppers
Alejandra Nieto, Holger Roehl
PDA Journal of Pharmaceutical Science and Technology Mar 2018, pdajpst.2017.008391; DOI: 10.5731/pdajpst.2017.008391

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