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A Mechanistic Understanding of Polysorbate 80 Oxidation in Histidine and Citrate Buffer Systems-Part 2

Laura M Doyle, Anant Navanithan Sharma, Ganapathy Gopalrathnam, Lihua Huang and Scott Bradley
PDA Journal of Pharmaceutical Science and Technology February 2019, pdajpst.2018.009639; DOI: https://doi.org/10.5731/pdajpst.2018.009639
Laura M Doyle
1 University of Kansas;
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Anant Navanithan Sharma
2 Eli Lilly and Company
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  • For correspondence: sharma_anant_n@lilly.com
Ganapathy Gopalrathnam
2 Eli Lilly and Company
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Lihua Huang
2 Eli Lilly and Company
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Scott Bradley
2 Eli Lilly and Company
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Article Information

pdajpst.2018.009639
DOI 
https://doi.org/10.5731/pdajpst.2018.009639
PubMed 
30770486

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Received October 26, 2018
  • Accepted January 28, 2019
  • Published online February 15, 2019.

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  • You are currently viewing a previous version of this article (February 15, 2019 - 07:38).
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Copyright & Usage 
Copyright © 2019, Parenteral Drug Association

Author Information

  1. Laura M Doyle1,
  2. Anant Navanithan Sharma2,3 (sharma_anant_n{at}lilly.com),
  3. Ganapathy Gopalrathnam2,
  4. Lihua Huang2 and
  5. Scott Bradley2
  1. 1 University of Kansas;
  2. 2 Eli Lilly and Company
  1. ↵* Corresponding author; email: sharma_anant_n{at}lilly.com

Cited By...

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  • Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping
    Judith J. Mittag, Marie-Luise Trutschel, Helen Kruschwitz, Karsten Mäder, Julia Buske, Patrick Garidel
    International Journal of Pharmaceutics: X 2022 4
  • Comparative analysis and mechanistic insights into polysorbate 80 stability differences in biopharmaceutical buffer systems
    Zhuan Cheng, Pengzhen Wang, Luting Liu, Quanmin Chen, Jeremy Guo
    European Journal of Pharmaceutics and Biopharmaceutics 2024 205
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PDA Journal of Pharmaceutical Science and Technology: 79 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 79, Issue 2
March/April 2025
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A Mechanistic Understanding of Polysorbate 80 Oxidation in Histidine and Citrate Buffer Systems-Part 2
Laura M Doyle, Anant Navanithan Sharma, Ganapathy Gopalrathnam, Lihua Huang, Scott Bradley
PDA Journal of Pharmaceutical Science and Technology Feb 2019, pdajpst.2018.009639; DOI: 10.5731/pdajpst.2018.009639

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A Mechanistic Understanding of Polysorbate 80 Oxidation in Histidine and Citrate Buffer Systems-Part 2
Laura M Doyle, Anant Navanithan Sharma, Ganapathy Gopalrathnam, Lihua Huang, Scott Bradley
PDA Journal of Pharmaceutical Science and Technology Feb 2019, pdajpst.2018.009639; DOI: 10.5731/pdajpst.2018.009639
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Keywords

  • EDTA
  • Polysorbate 80 (PS80)
  • Citrate
  • histidine
  • oxidation
  • Phosphate

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