Abstract
The potential capability of a focused ultrasound technique for in-process measurement of suspended particles in water systems was studied by challenging the focused ultrasound instrumentation with various sizes and concentrations of spheres in a single pass test system. Correlation between particle counts per unit time as measured by focused ultrasound and particles per unit volume as measured by a HIAC particle counter was determined for 1–5-, 10-, and 20-µm spheres. Correlation coefficients were 0.97 and 0.90 for the 10-µm and 20-µm spheres, respectively. The ultrasound transducer used does not appear to be sensitive enough to detect the 1–5-µm spheres. The uncertainty involved in expressing particle counts as measured by focused ultrasound on a volume basis is discussed.
- Received April 28, 1981.
- Accepted June 19, 1981.
- Copyright © Parenteral Drug Association. All rights reserved.
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