Abstract
Filtration of test solutions through a 0.2 μm-rated pore size pleated membrane filter cartridge, designed for operation in a tangential (crossflow) mode, shows that throughputs with such systems are many fold greater than with comparable uni-directional (dead end) cartridge filters. Although the crossflow cartridge is more expensive than the traditional cartridge filter, cost per liter of filtrate is reduced by at least 50% because of the improvement in throughput. An example of biologic processing illustrates the unusual flexibility of the crossflow system. This study compares conventional uni-directional filtration with the practice and economics of a new tangential flow (crossflow) microporous filter cartridge system. Studies with biological solutions, water, and parenteral fluids invariably showed that tangential flow filtrate throughputs were many fold greater than for unidirectional microporous filtration and that significant economic justification exists for the use of tangential flow filtration in many pharmaceutical applications.
- Received May 15, 1981.
- Accepted July 29, 1981.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.