Abstract
The chemical stabilities of 7 antibiotics, ampicillin. carbenicillin. cefazolin. cefoxitin, cephalothin. moxalactam. and penicillin G and hydrocortisone sodium succinate when mixed with metronidazole injection have been studied using stability-indicating high-performance liquid chromatography methods. After 3 days of storage at 25° and 12 days at 5°. metronidazole in all solutions was determined to be stable. Hydrocortisone sodium succinate solution did not decompose significantly during 7 days at 25° and 12 days at 5°. Three antibiotics, carbenicillin. cefazolin, and penicillin G were stable for 3 days at 25° (loss in potency less than 10%); and cefoxitin and moxalactam for only 2 days. Ampicillin was stable only for one day at 25° and cephalothin lost more than 10% of the potency in one day. All the antibiotic solutions in metronidazole injection were stable for 12 days at 5°.
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