Abstract
Endotoxin-spiked experimental lots of an iodinated nonionic x-ray contrast solution and a citrated saline solution were studied to determine the effectiveness of heating and pH on reduction of endotoxin levels. Inactivation of the Escherichia coli endotoxins in both 50 mM citrate saline and the nonionic contrast solution was accomplished when the medium was heated (80–90 °C) at pH = 3 or when it was autoclaved (121 °C) at neutral pH.
- Received September 15, 1986.
- Accepted November 26, 1986.
- Copyright © Parenteral Drug Association. All rights reserved.
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