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Research ArticleRESEARCH

In Vitro Iontophoretic Delivery of Nicorandil

Bijaya Ghosh, Rashmi Baser, Uma A. Patil and B. M. Dinesh
PDA Journal of Pharmaceutical Science and Technology January 2010, 64 (1) 20-27;
Bijaya Ghosh
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  • For correspondence: bijayadd@yahoo.co.in
Rashmi Baser
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Uma A. Patil
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B. M. Dinesh
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Abstract

The present investigation is aimed at assessing the iontophoretic permeability of nicorandil to evaluate its feasibility for the development of an actively delivered transdermal system. Excised porcine skin was used for permeation study, and steady state flux was optimized with respect to donor concentration, current density, and voltage. Constant current iontophoresis was carried out at 0.3, 0.5, and 0.7 mA/cm2, whereas constant voltage studies were carried out at 3, 5, and 6.5 V. The effect of donor drug concentration (11.8, 55.8, and 104.8 mg/mL) was studied at the optimized condition of 5 V. An apparent increase in steady state flux was observed in constant current studies, but the increment over the passive diffusion was statistically insignificant (P > 0.05). In contrast, steady state flux was found to be higher than that of passive fluxes when permeation was carried out at 5 and 6.5 V (P < 0.001). Incorporation of alcohol in the donor vehicle increased solubility, but there was a tradeoff in terms of lag time. Conformity with the Nernst-Planck convective transport model suggested that electroosmosis was the dominant mechanism of permeation.

  • Nicorandil
  • Electroosmosis
  • Iontophoresis
  • Target flux
  • Porcine skin
  • © PDA, Inc. 2010
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PDA Journal of Pharmaceutical Science and Technology: 64 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 64, Issue 1
January/February 2010
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In Vitro Iontophoretic Delivery of Nicorandil
Bijaya Ghosh, Rashmi Baser, Uma A. Patil, B. M. Dinesh
PDA Journal of Pharmaceutical Science and Technology Jan 2010, 64 (1) 20-27;

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In Vitro Iontophoretic Delivery of Nicorandil
Bijaya Ghosh, Rashmi Baser, Uma A. Patil, B. M. Dinesh
PDA Journal of Pharmaceutical Science and Technology Jan 2010, 64 (1) 20-27;
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