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Research ArticleRESEARCH

In Vitro Iontophoretic Delivery of Nicorandil

Bijaya Ghosh, Rashmi Baser, Uma A. Patil and B. M. Dinesh
PDA Journal of Pharmaceutical Science and Technology January 2010, 64 (1) 20-27;
Bijaya Ghosh
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  • For correspondence: bijayadd@yahoo.co.in
Rashmi Baser
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Uma A. Patil
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B. M. Dinesh
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References

  1. 1.↵
    1. Daiber A.,
    2. Wenzel P.,
    3. Oelze M.,
    4. Munzel T.
    New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance. Clin. Res. Cardiol. 2008, 97 ( 1) 12– 20.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. Udaykumar P.,
    2. Adhikari P,
    3. Periera P.
    Safety and efficacy of nicorandil in chronic stable angina—a double blind comparative randomised trial with isosorbide mononitrate. Journal, Indian Academy of Clinical Medicine 2003, 4 ( 3), 205– 209.
    OpenUrl
  3. 3.↵
    IONA study group. Effect of nicorandil on coronary events in patients with stable angina: the impact of nicorandil in angina (IONA) randomized trial. Lancet 2002, 359 ( 9314), 1269– 1275.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Krishnaiah Y. S. R.,
    2. Chandrasekhar D. V.,
    3. Rama B.,
    4. Jayaram B.,
    5. Satyanarayana V.,
    6. Al-Saidan S. M.
    In vivo evaluation of limonene-based transdermal therapeutic system of nicorandil in healthy human volunteers. Skin Pharmacol. Physiol. 2005, 18 ( 6), 263– 272.
    OpenUrlPubMed
  5. 5.↵
    1. Tipre D. N.,
    2. Vavia P. R.
    Formulation optimization and stability study of transdermal therapeutic system of nicorandil. Pharm. Dev. Technol. 2002, 7 ( 3), 325– 332.
    OpenUrlPubMed
  6. 6.↵
    1. Al-Saidan S. M.,
    2. Krishnaiah Y. S. R.,
    3. Chandrashekar D. V.,
    4. Lalla J. K.,
    5. Rama B.,
    6. Jayaram B.,
    7. Bhaskar P.
    Formulation of an HPMC gel drug reservoir system with ethanol-water as a solvent system and Limonene as a penetration enhancer for enhancing in-vitro transdermal delivery of nicorandil. Skin Pharmacol. Physiol. 2004, 17 ( 6), 310– 320.
    OpenUrlPubMed
  7. 7.↵
    1. Chandrashekar D. V.,
    2. Rama B.,
    3. Krishnaiah Y. S. R.,
    4. Al-Saidan S. M.
    Effect of nerodilol and carvone on in vitro permeation of nicorandil across rat epidermal membrane. Drug Dev. Ind. Pharm. 2006, 32 ( 4), 423– 435.
    OpenUrlPubMed
  8. 8.↵
    1. Jain A.,
    2. Ghosh B.,
    3. Rajgor N.,
    4. Desai B. G.
    Passive and iontophoretic permeation of glipizide. Eur. J. Pharm. Biopharm. 2008, 69 ( 3), 958– 963.
    OpenUrlPubMed
  9. 9.↵
    1. Andrensek S.,
    2. Smidovnik A.,
    3. Pecavar A.,
    4. Prosek M.
    Routine and sensitive method for determination of nicorandil in human plasma developed for liquid chromatography with ultraviolet and mass spectrometric detection. J. Chromatogr., B. Biomed. Sci. Appl. 1999, 735 ( 1), 103– 109.
    OpenUrlPubMed
  10. 10.↵
    1. Schwarzenbach R. P.,
    2. Gschwend P. M.,
    3. Imoden D. M.
    Environmental Organic Chemistry, 2nd ed. J. Wiley and Sons: New York, 2004.
  11. 11.↵
    1. Thomas N. S.,
    2. Panchagnula R.
    Transdermal delivery of zidovudine: effect of vehicles on permeation across rat skin and their mechanism of action. Eur. J. Pharm. Sci. 2003, 18 ( 1), 71– 79.
    OpenUrlPubMed
  12. 12.↵
    1. Suwanpidokkul N.,
    2. Thongnopnua P.,
    3. Umprayn K.
    Transdermal delivery of zidovudine (AZT): the effects of vehicles, enhancers, and polymer membranes on permeation across cadaver pig skin. AAPS PharmSciTech 2004, 5 ( 3), e48.
    OpenUrlPubMed
  13. 13.↵
    1. Mutalik S.,
    2. Udapa N.
    Pharmacological evaluation of membrane-moderated transdermal system of glibenclamide. Clin. Exp. Pharmacol. Physiol. 2006, 33 ( 1–2), 17– 26.
    OpenUrlPubMed
  14. 14.↵
    1. Peck K. D.,
    2. Ghanem A. H.,
    3. Higuchi W. I.
    Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane. Pharm. Res. 1994, 11 ( 9), 1306– 1314.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Frydman A.
    Pharmacokinetic profile of nicorandil in humans: an overview. J. Cardiovasc. Pharamcol. 1992, 20 ( Suppl. 3), S34– S44.
    OpenUrl
  16. 16.↵
    1. Minghetti P.,
    2. Casiraghi A.,
    3. Montanari L.,
    4. Monzani M. V.
    In vitro skin permeation of sinitrodil, a member of a new class of nitrovasodilator drugs. Eur. J. Pharm. Sci. 1999, 7 ( 3), 231– 236.
    OpenUrlPubMed
  17. 17.↵
    1. Jamakandi V. G.,
    2. Ghosh B.,
    3. Desai B. G.,
    4. Khanam J.
    Recent trends in transdermal cardiovascular therapy. Ind. J. Pharm. Sci. 2006, 68 ( 5), 556– 561.
    OpenUrl
  18. 18.↵
    Health advisory for fentanyl patches for nurses practitioner. Amer. J. Prim. Healthcare 2005, 30, 74.
    OpenUrl
  19. 19.↵
    1. Hawkins G. S.,
    2. Reifenrath W. G.
    Influence of skin source, penetration cell fluid, and partition coefficient on in vitro skin penetration. J. Pharm. Sci. 1986, 75 ( 4), 378– 381.
    OpenUrlPubMed
  20. 20.↵
    1. Kasting G. B.,
    2. Bowman L. A.
    DC electrical properties of frozen, excised human skin. Pharm. Res. 1990, 7 ( 2), 134– 143.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Yamamoto T.,
    2. Yamamoto Y.
    Dielectric constant and resistivity of epidermal stratum corneum. Med. Biol. Eng. 1976, 14 ( 5), 494– 500.
    OpenUrlPubMed
  22. 22.↵
    1. Lin R. Y.,
    2. Ou Y. C.,
    3. Chen W. Y.
    The role of electroosmotic flow on in vitro transdermal iontophoresis. J. Controlled Release 1997, 43 ( 1), 23– 33.
    OpenUrl
  23. 23.↵
    1. Murthy S. N.,
    2. Zhao Y.-L.,
    3. Sen A.,
    4. Hui S. W.
    Cyclodextrin enhanced transdermal delivery of piroxicam and carboxyfluorescein by electroporation. J. Controlled Release 2004, 99 ( 3), 393– 403.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. Li K. S.,
    2. Ghanem A. H.,
    3. Peck K. D.,
    4. Higuchi W. I.
    Characterization of the transport pathways induced during low to moderate voltage iontophoresis in human epidermal membrane. J. Pharm. Sci. 1998, 87 ( 1), 40– 48.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Imanidis G.,
    2. Luetolf P.
    An extended model based on the modified nernst-planck equation for describing transdermal iontophoresis of weak electrolytes. J. Pharm. Sci. 2006, 95 ( 7), 1434– 1447.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Higuchi W. I.,
    2. Li K. S.,
    3. Ghanem A. H.,
    4. Zhu H.,
    5. Song Y.
    Mechanistic aspects of iontophoresis in human epidermal membrane. J. Controlled Release 1999, 62 ( 1–2), 13– 23.
    OpenUrlPubMed
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PDA Journal of Pharmaceutical Science and Technology: 64 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 64, Issue 1
January/February 2010
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In Vitro Iontophoretic Delivery of Nicorandil
Bijaya Ghosh, Rashmi Baser, Uma A. Patil, B. M. Dinesh
PDA Journal of Pharmaceutical Science and Technology Jan 2010, 64 (1) 20-27;

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In Vitro Iontophoretic Delivery of Nicorandil
Bijaya Ghosh, Rashmi Baser, Uma A. Patil, B. M. Dinesh
PDA Journal of Pharmaceutical Science and Technology Jan 2010, 64 (1) 20-27;
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