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Review ArticleReview

Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems

Dattatraya Manohar Shinkar, Avinash Sridhar Dhake and Chitral Mallikarjuna Setty
PDA Journal of Pharmaceutical Science and Technology September 2012, 66 (5) 466-500; DOI: https://doi.org/10.5731/pdajpst.2012.00877
Dattatraya Manohar Shinkar
1Department of Pharmaceutics, KCT'S RGS College of Pharmacy, Anjaneri, Nashik, Maharashtra, India;
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  • For correspondence: dattashinkar@gmail.com
Avinash Sridhar Dhake
2Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Dhamangaon, Nashik, Maharashtra, India; and
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Chitral Mallikarjuna Setty
3Department of Pharmaceutics, Vishnu College of Pharmaceutical Education and Reaserch, Medak, Hyderabad, AP, India
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Abstract

Since the early 1980s the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. The various advantages associated with these systems made buccal drug delivery as a novel route of drug administration. It prolongs the residence time of the dosage form at the site of application. These systems remain in close contact with the absorption tissue, the mucous membrane, and thus contribute to improved and/or better therapeutic performance of the drug and of both local and systemic effects. This review highlights the anatomy and structure of oral mucosa, mechanism and theories of mucoadhesion, factors affecting mucoadhesion, characteristics and properties of desired mucoadhesive polymers, various types of dosage forms, and general considerations in design of mucoadhesive buccal dosage forms, permeation enhancers, and evaluation methods.

LAY ABSTRACT: Over the past few decades the mucoadhesive buccal drug delivery system has received a great deal of attention to develop mucoadhesive dosage forms to enable the prolonged retention at the site of action, providing a controlled release of drug for improved therapeutic outcome. Mucoadhesive drug delivery gives facility to include a permeation enhancer/enzyme inhibitor or pHmodifier in the formulation and versatility in designing as multidirectional or unidirectional release systems for local and systemic action. Local delivery to tissues of the oral cavity has a number of applications, including treatment of local conditions such as periodontal disease, bacterial and fungal infections, and aphthous stomatitis and vesiculo bullous diseases. For the treatment of chronic diseases, the mucoadhesive buccal drug delivery system allows easily accessibility and is generally well-accepted for administeringdrugs by systemic action.

  • Mucoadhesion
  • Oral mucosa
  • Buccal route
  • Penetration enhancer
  • Therapeutic performance
  • © PDA, Inc. 2012
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PDA Journal of Pharmaceutical Science and Technology: 66 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 66, Issue 5
September/October 2012
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Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems
Dattatraya Manohar Shinkar, Avinash Sridhar Dhake, Chitral Mallikarjuna Setty
PDA Journal of Pharmaceutical Science and Technology Sep 2012, 66 (5) 466-500; DOI: 10.5731/pdajpst.2012.00877

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Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems
Dattatraya Manohar Shinkar, Avinash Sridhar Dhake, Chitral Mallikarjuna Setty
PDA Journal of Pharmaceutical Science and Technology Sep 2012, 66 (5) 466-500; DOI: 10.5731/pdajpst.2012.00877
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  • Article
    • Abstract
    • Introduction
    • Advantages of the Mucoadhesive Buccal Drug Delivery System
    • Limitations of the Mucoadhesive Buccal Drug Delivery System
    • Anatomy and Structure of the Oral Cavity
    • Composition of Mucus Layer
    • Functions of the Mucus Layer
    • Structure of the Oral Mucosa
    • Buccal Absorption
    • Assessing Drug Permeation through the Buccal Mucosa
    • Buccal Penetration Enhancers (31, 32)
    • Classification and Examples of Membrane Permeation Enhancers
    • Mechanism of Permeation Enhancers
    • Bioadhesion/Mucoadhesion
    • Mechanism of Mucoadhesion/Bioadhesion
    • Theories on Mucoadhesion/Bioadhesion
    • Factors Affecting Mucoadhesion
    • Buccal Mucoadhesive Polymers
    • Ideal Characteristics of Buccal Mucoadhesive Polymers (24)
    • New-Generation Mucoadhesive Polymers
    • Buccal Mucoadhesive Dosage Forms
    • General Considerations in Designing Dosage Forms
    • Approaches to the Use of Mucoadhesive Formulations
    • Relevant Mucoadhesive Buccal Dosage Forms
    • Evaluation of Mucoadhesive Buccal Drug Delivery Systems
    • In Vitro Techniques
    • Work of Adhesion
    • Other In Vitro Methods
    • In Vivo Techniques
    • Method
    • Ex Vivo Residence Time
    • In Vivo Residence Time
    • Current Market Status of Buccal Drug Delivery Systems
    • Conclusion
    • Conflict of Interest Declaration
    • Acknowldgements
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

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Keywords

  • Mucoadhesion
  • Oral mucosa
  • Buccal route
  • Penetration enhancer
  • Therapeutic performance

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