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Review ArticleReview

Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems

Dattatraya Manohar Shinkar, Avinash Sridhar Dhake and Chitral Mallikarjuna Setty
PDA Journal of Pharmaceutical Science and Technology September 2012, 66 (5) 466-500; DOI: https://doi.org/10.5731/pdajpst.2012.00877
Dattatraya Manohar Shinkar
1Department of Pharmaceutics, KCT'S RGS College of Pharmacy, Anjaneri, Nashik, Maharashtra, India;
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  • For correspondence: dattashinkar@gmail.com
Avinash Sridhar Dhake
2Department of Pharmaceutics, S.M.B.T. College of Pharmacy, Dhamangaon, Nashik, Maharashtra, India; and
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Chitral Mallikarjuna Setty
3Department of Pharmaceutics, Vishnu College of Pharmaceutical Education and Reaserch, Medak, Hyderabad, AP, India
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References

  1. 1.↵
    1. Robinson D. H.,
    2. Mauger J. W.
    Drug delivery systems. Am. J. Hosp. Pharm. 1991, 48, S14–S23.
    OpenUrlAbstract
  2. 2.↵
    1. Ullyot S. C.
    Paediatric premedication. Can. J. Anaesth. 1992, 39, 533–536.
    OpenUrlPubMedWeb of Science
  3. 3.↵
    1. Bandyopadhyay A. K.,
    2. Sudhakar Y.
    Advances in buccal adhesive drug delivery. Drug Delivery Technology 2006, 6 (6), 51–55.
    OpenUrl
  4. 4.↵
    1. Giannola L. I.,
    2. De Caro V.,
    3. Giandalia G.,
    4. Siragusa M. G.,
    5. Campisi G.
    Current status in buccal drug delivery. Wolff Pharmaceutical Technology Europe. May 1, 2008.
  5. 5.↵
    1. Khanna R.,
    2. Agarwal S. P.,
    3. Alka A.
    Mucoadhesive buccal drug delivery: a potential alternative to conventional therapy. Indian J. Pharm. Sci. 1998, 60 (l), 1–11.
    OpenUrl
  6. 6.↵
    1. Miller N. S.,
    2. Chittchang M.,
    3. Johnston T. P.
    The use of mucoadhesive polymers in buccal drug delivery. Adv. Drug Deliv. Rev. 2005, 57 (1), 1666–1691.
    OpenUrlPubMed
  7. 7.↵
    1. Vyas S. P.,
    2. Khar R. K.
    Controlled Drug Delivery—Concepts and Advances, 1st ed.; Vallabh Prakashan: New Delhi, 2002.
  8. 8.↵
    1. Veillard M. M.,
    2. Longer M.,
    3. Martens T. W.,
    4. Robinson J. R.
    Preliminary studies of oral mucosal delivery of peptide drugs. J. Controlled Release 1987, 6 (1), 123–131.
    OpenUrl
  9. 9.↵
    1. Alka G.,
    2. Sanjay G.,
    3. Khar R. K.
    Mucoadhesive buccal drug delivery systems: a review. Indian Drugs 1992, 13 (29), 586–593.
    OpenUrl
  10. 10.↵
    1. Khanna R.,
    2. Agarwal S. P.,
    3. Alka A.
    Mucoadhesive buccal drug delivery: a potential alternative to conventional therapy. Indian J. Pharm Sci. 1998, 60 (l), 1–11.
    OpenUrl
  11. 11.↵
    1. Lehr C. M.
    Lectin-mediated drug delivery: the second generation of bioadhesives. J. Controlled Release 2000, 65 (1–2), 19–29.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Meyer J.,
    2. Squier C. A.,
    3. Gerson S. J.
    1. Chen Y. S.,
    2. Squier C. A.
    The Ultrastructure of the Oral Epithelium. In The Structure and Function of Oral Mucosa; Meyer J., Squier C. A., Gerson S. J. Eds.; Pergamon Press: Oxford, 1984; pp 7–30.
  13. 13.↵
    1. Harris D.,
    2. Robinson J. R.
    Drug delivery via the mucous membranes of the oral cavity. J. Pharm Sci. 1992, 81 (1), 1–10.
    OpenUrlPubMedWeb of Science
  14. 14.↵
    1. Hillery A. M.,
    2. Lloyd A. W.
    Oral Transmucosal Drug Delivery, Controlled and Targeted Drug Delivery System; Taylor & Francis: London and New York, 2001; p 182.
  15. 15.↵
    1. de Boer A. G.,
    2. van Hoogdalem E. J.,
    3. Breimer D. D.
    Improvement of drug absorption through enhancers. Eur. J. Drug Metab. Pharmacokinet. 1990, 15 (2), 155–157.
    OpenUrlPubMedWeb of Science
  16. 16.↵
    1. Singh J.,
    2. Roberts M. S.
    Transdermaldelivery of drugs by iontophoresis: a review. Drug Des. Deliv. 1989, 4 (1), 1–12.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Motwani J. G.,
    2. Lipworth B. J.
    Clinicalpharmacokinetics of drugs administered buccally and sublingually. Clin. Pharmacokinet. 1991, 21 (2), 83–94.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. van Hoogdalem E.,
    2. de Boer A. G.,
    3. Breimer D. D.
    Pharmacokineticsof rectal drug administration. Part I: general considerationsand clinical applications of centrally acting drugs. Clin. Pharmacokinet, 1991, 21 (1), 11–26.
    OpenUrlPubMedWeb of Science
  19. 19.↵
    1. Weinberg D. S.,
    2. Inturrisi C. E.,
    3. Reidenberg B.,
    4. Moulin D. E.,
    5. Nip T. J.,
    6. Wallenstein S.,
    7. Houde R. W.,
    8. Foley K. M.
    Sublingualabsorption of selected opioid analgesics. Clin. Pharmacol. Ther. 1988, 44 (3), 335–342.
    OpenUrlPubMedWeb of Science
  20. 20.↵
    Editorial. Administration of drugs by the buccal route. Lancet 1987, 1, 666–667.
    OpenUrlPubMedWeb of Science
  21. 21.↵
    1. de Vries M. E.,
    2. Boddé H. E.,
    3. Verhoef J. C.,
    4. Junginger H. E.
    Developments in buccal drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 1991, 8 (3), 271–303.
    OpenUrlPubMedWeb of Science
  22. 22.↵
    1. Jantzen J. P.,
    2. Erdmann K.,
    3. Witton P. K.,
    4. Klein A. M.
    Theeffect of rectal pH values on the absorption of methohexital. Anaesthetist 1986, 35 (8), 496–499.
    OpenUrlPubMedWeb of Science
  23. 23.↵
    1. Kimura T.,
    2. Yamano H.,
    3. Tanaka A.,
    4. Matsumara T.,
    5. Ueda M.,
    6. Ogawara K.
    Transport of D-glucose across cultured stratified cell layer of human oral mucosal cells. J. Pharm. Pharmacol. 2002, 54 (2), 213–219.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. Sudhakar Y.,
    2. Kuotsu K.,
    3. Bandyopadhyay A. K.
    Buccal bioadhesive drug delivery—a promising option for orally less efficient drugs. J. Controlled Release 2006, 114 (1), 15–40.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Randhawa M. A.,
    2. Malik S. A.,
    3. Javed M.
    Buccal absorption of weak acidic drugs is not related to their degree of ionization as estimated from the Henderson-Hasselbalch equation. Pakistan J. Med. Res. 2003, 42 (2), 45–49.
    OpenUrl
  26. 26.↵
    1. Attia M. A.,
    2. El-Gibaly I.,
    3. Shaltout S. E.,
    4. Fetih G. N.
    Transbuccal permeation, anti-inflammatory activity and clinical efficacy of piroxicam formulated in different gels. Int. J. Pharm. 2004, 276 (1–2), 11–28.
    OpenUrlPubMed
  27. 27.↵
    1. van der Mei H. C.,
    2. White D. J.,
    3. Busscher H. J.
    Biomechanical analysis of shoulder arthroplasty. Arch. Oral Biol. 2004, 49, 671–673.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Birudaraj R.,
    2. Mahalingam R.,
    3. Li X.,
    4. Jasti B. R.
    Advances in buccal drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 2005, 22 (3), 295–300.
    OpenUrlPubMed
  29. 29.↵
    1. van Eyk A. D.,
    2. van der Bijl P.
    Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa. Arch. Oral Biol. 2004, 49 (5), 387–392.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Nielsen H. M.,
    2. Rassing M. R.
    TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and beta-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa. Int. J. Pharm. 2000, 194 (2), 155–167.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Pramod Kumar T. M.,
    2. Desai K. G.,
    3. Shivkumar H. G.
    Mechanism of buccal permeation enhancers. Indian J. Pharm. Educ. 2002, 36 (3), 147–151.
    OpenUrl
  32. 32.↵
    1. McElnay A. C.,
    2. Swarbrick J.,
    3. Boyloan J. C.
    Encyclopedia of Pharmaceutical Technology; Marcel Dekker: New York; 1988, Vol. 2; p 189.
    OpenUrl
  33. 33.↵
    1. Nicolazzo J. A.,
    2. Reed B. L.,
    3. Finnin B. C.
    Buccal penetration enhancers—how do they really work? J. Controlled Release 2005, 105 (1–2), 1–15.
    OpenUrl
  34. 34.↵
    1. Williams A. C.,
    2. Barry B. W.
    Penetration enhancer. Adv. Drug Deliv. Rev. 2004, 56 (5), 603–618.
    OpenUrlCrossRefPubMedWeb of Science
  35. 35.↵
    1. Starokadomskyy P. L.,
    2. Dubey I. Y.
    New absorption promoter for the buccal delivery: preparation and characterization of lysalbinic acid. Int. J. Pharm. 2006, 308 (1–2), 149–154.
    OpenUrlPubMed
  36. 36.↵
    1. Lavon I.,
    2. Grossman N.,
    3. Joseph K.,
    4. Kimmel E.,
    5. Enden G.
    Bubble growth within the skin by rectified diffusion might play a significant role in sonophoresis. J. Controlled Release 2007, 117 (2), 246–255.
    OpenUrlPubMed
  37. 37.↵
    1. Mitragotri S.,
    2. Kost J.
    Low-frequency sonophoresis: a review. Adv. Drug Deliv. Rev. 2004, 56 (5), 589–601.
    OpenUrlCrossRefPubMedWeb of Science
  38. 38.↵
    1. Kalia Y. N.,
    2. Naik A.,
    3. Garrison J.,
    4. Guy R. H.
    Iontophoretic drug delivery. Adv. Drug Deliv. Rev. 2004, 56 (5), 619–658.
    OpenUrlCrossRefPubMedWeb of Science
  39. 39.↵
    1. Denet A. R.,
    2. Vanbever R.,
    3. Preat V.
    Skin electroporation for transdermal and topical delivery. Adv. Drug Deliv. Rev. 2004, 56 (5), 659–674.
    OpenUrlCrossRefPubMedWeb of Science
  40. 40.↵
    1. Longer M. A.,
    2. Robinson J. R.
    Fundamental aspects of bioadhesion. Pharm. Int. 1986, 7, 114–117.
    OpenUrl
  41. 41.↵
    1. Gandhi R. B.,
    2. Robinson J. R.
    Oral cavity as a site for bioadhesive drug delivery. Adv. Drug Deliv. Rev. 1994, 13 (1–2), 43–74.
    OpenUrl
  42. 42.↵
    1. Duchěne D.,
    2. Touchard F.,
    3. Peppas N. A.
    Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev. Ind. Pharm. 1988, 14 (2–3), 283–318.
    OpenUrl
  43. 43.↵
    1. Peppas N. A.
    Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J. Controlled Release 1985, 2, 257.
    OpenUrlCrossRef
  44. 44.↵
    1. Ugwoke M. I.,
    2. Agu R. U.,
    3. Verbeke N.,
    4. Kinget R.
    Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv. Drug Deliv. Rev. 2005, 57 (11), 1640–1665.
    OpenUrlCrossRefPubMed
  45. 45.↵
    1. van Wachem P. B.,
    2. Beugeling T.,
    3. Feijen J.,
    4. Bantjes A.,
    5. Detmers J. P.,
    6. van Aken W. G.
    Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities. Biomaterials 1985, 6 (6), 403–408.
    OpenUrlCrossRefPubMedWeb of Science
  46. 46.↵
    1. Dodou P.,
    2. Breedveld P.,
    3. Wieringa P. A.
    Mucoadhesives in the gastrointestinal tract: revisiting the literature for novel applications. Eur. J. Pharm. Biopharm. 2005, 60 (1), 1–16.
    OpenUrlCrossRefPubMedWeb of Science
  47. 47.↵
    1. Derjaguin B. V.,
    2. Smilga V. P.
    The electronic theory of adhesion. In: Adhesion: Fundamentals and Practice; University of Notingham, England andGordon & Breach: New York, 1996.
  48. 48.↵
    1. Andrews G. P.,
    2. Laverty T. P.,
    3. Jones D. S.
    Mucoadhesive polymeric platforms for controlled drug delivery. Eur. J. Pharm. Biopharm. 2009, 71 (3), 505–518.
    OpenUrlCrossRefPubMed
  49. 49.↵
    1. Lee J. W.,
    2. Park J. H.,
    3. Robinson J. R.
    Bioadhesive-based dosage forms: the next generation. J. Pharm. Sci. 2000, 89 (7), 850–866.
    OpenUrlCrossRefPubMed
  50. 50.↵
    1. Gupta A.,
    2. Garg S.,
    3. Khar R. K:
    Mucoadhesive buccal drug delivery systems: areview. Indian Drugs 1992, 29 (13), 586–593.
    OpenUrl
  51. 51.↵
    1. Jain N. K.
    1. Khar K.,
    2. Ahuja A.,
    3. Javed A.
    Mucoadhesive Drug Delivery. In Controlled and Novel Drug Delivery, 1st ed.; Jain N. K. Ed.; CBS Publishers and Distributors, New Delhi, 1997.
  52. 52.↵
    1. Jimenez-Castellanos M. R.,
    2. Zia H.,
    3. Rhodes C. T.
    Mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm. 1993, 19 (1–2), 143–194.
    OpenUrl
  53. 53.↵
    1. Ahuja A.,
    2. Khar R. K.,
    3. Ali J.
    Mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm. 1997, 23 (5), 489–515.
    OpenUrl
  54. 54.↵
    1. Wise D. L.
    1. Peppas N. A.,
    2. Little M. D.,
    3. Huang Y.
    Bioadhesive ControlledRelease Systems. In Handbook of Pharmaceutical Controlled Release Technology; Wise D. L. Ed.; Marcel Dekker: New York, 2000; pp 255–269.
  55. 55.↵
    1. Tiwari D.,
    2. Goldman D.,
    3. Sause R.,
    4. Madan P. L.
    Evaluation of polyoxyethylene homopolymers for buccal bioadhesive drug delivery device formulations. AAPS PharmSci 1999, 1 (3), 50–57.
    OpenUrl
  56. 56.↵
    1. Huang Y.,
    2. Leobandung W.,
    3. Foss A.,
    4. Peppas N. A.
    Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces. J. Controlled Release 2000, 65 (1–2), 63–71.
    OpenUrlCrossRefPubMedWeb of Science
  57. 57.↵
    1. Park K.,
    2. Robinson J. R.
    Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels. Pharm Res. 1987, 4 (6), 457–464.
    OpenUrlPubMed
  58. 58.↵
    1. Hagerstrom H.,
    2. Paulsson M.,
    3. Edsman K.
    Evaluation of mucoadhesion for two polyelectrolyte gels in simulated physiological conditions using a rheological method. Eur. J. Pharm. Sci. 2000, 9 (3), 301–309.
    OpenUrlPubMed
  59. 59.↵
    1. Sigurdsson H.,
    2. Loftsson T.,
    3. Lehr C.
    Assessment of mucoadhesion by a resonant mirror biosensor. Int. J. Pharm. 2006, 325 (1–2), 75–81.
    OpenUrlPubMed
  60. 60.↵
    1. Mortazavi S. A.,
    2. Smart J.
    An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J. Controlled Release 1993, 25 (3), 197–203.
    OpenUrl
  61. 61.↵
    1. Flory P. J.
    Principlse of Polymer Chemistry; Cornell University Press: Ithaca, New York, 1953; pp 541–556.
  62. 62.↵
    1. Park K.,
    2. Robinson J. R.
    Bioadhesive polymers as platforms for oral controlled drug delivery: method to study bioadhesion. Int J. Pharm. 1984, 19 (2), 107–127.
    OpenUrlCrossRefWeb of Science
  63. 63.↵
    1. Anderson J. M.,
    2. Kim S. W.
    1. Park K.,
    2. Ch'ng H. S.,
    3. Robinson J. R.
    Alternative approaches to oral-controlled drug delivery: bioadhesive and in situ systems. In Recent Advances in Drug Delivery Systems; Anderson J. M., Kim S. W. Eds.; Plenum Press: New York, 1984; p 163.
  64. 64.↵
    1. Ch'ng H. S.,
    2. Park K.,
    3. Kelly P.,
    4. Robinson J. R.
    Bioadhesive polymers as platform for oral controlled drug delivery. II. Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J. Pharm Sci. 1985, 74 (4), 399–404.
    OpenUrlPubMed
  65. 65.↵
    1. Park H.,
    2. Amiji M.,
    3. Park K.
    Mucoadhesive hydrogels effective at neutral pH. Proc. Int. Symp. Control. Release Bioact. Mater. 1989, 16, 217–218.
    OpenUrl
  66. 66.↵
    1. Asane G. S.,
    2. Nirmal S. A.,
    3. Rasal K. B.,
    4. Naik A. A.,
    5. Mahadik M. S.,
    6. Rao Y. R.
    Polymers for mucoadhesive drug delivery system: acurrent status. Drug Dev. Ind. Pharm. 2008, 34 (11), 1246–1266.
    OpenUrlPubMed
  67. 67.↵
    1. Salamat-Miller N.,
    2. Chittchang M.,
    3. Johnston T. P.
    The use of mucoadhesive polymers in buccal drug delivery. Adv. Drug. Del. Rev. 2005, 57 (11), 1666–1691.
    OpenUrlPubMed
  68. 68.↵
    1. Swarbrick J.,
    2. Boylan J. C.
    1. Kamath K. R.,
    2. Park K.
    Mucosal Adhesive Preparations. In Encyclopedia of Pharmaceutical Technology; Swarbrick J., Boylan J. C. Eds.; Marcel Dekker: New York, 1994; pp 133–138.
  69. 69.↵
    1. Lehr C. M.,
    2. Poelma F. C. G.,
    3. Junginger H. E.,
    4. Tukker J. J.
    An estimate of turnover time of intestinal mucus gel layer in the rats, in situ loop. Int. J. Pharm. 1991, 70 (1), 235–240.
    OpenUrl
  70. 70.↵
    1. Ugwoke M. I.,
    2. Agu R. U.,
    3. Verbeke N.,
    4. Kinget R.
    Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives. Adv. Drug Del. Rev. 2005, 57 (11), 1640–1665.
    OpenUrlCrossRefPubMed
  71. 71.↵
    1. Shojaei A. H.
    Buccal mucosa as a route for systemic drug delivery: a review. J. Pharm. Pharm. Sci. 1998, 1 (1), 15–30.
    OpenUrlPubMed
  72. 72.↵
    1. Gu J. M.,
    2. Robinson J. R.,
    3. Leung S. H.
    Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. Crit. Rev. Ther. Drug Carr. Syst. 1998, 5 (1), 21–67.
    OpenUrl
  73. 73.↵
    1. Lee J. W.,
    2. Park J. H.,
    3. Robinson J. R.
    Bioadhesive-based dosage forms: the next generation. J. Pharm. Sci. 2000, 89 (7), 850–866.
    OpenUrlCrossRefPubMed
  74. 74.↵
    1. Andrews G. P.
    Mucoadhesive polymeric platforms for controlled drug delivery. Eur. J. Pharm. Biopharm. 2009, 71, 505–518.
    OpenUrlCrossRefPubMed
  75. 75.↵
    1. Onishi H.,
    2. Machida Y.
    Biodegradation and distribution of water soluble chitosan in mice. Biomaterials 1999, 20, 175–182.
    OpenUrlCrossRefPubMedWeb of Science
  76. 76.↵
    1. Clark M. A.,
    2. Hirst B.,
    3. Jepson M.
    Lectin-mediated mucosal delivery of drugs and microparticles. Adv. Drug Deliv. Rev. 2000, 43 (2–3), 207–223.
    OpenUrlCrossRefPubMedWeb of Science
  77. 77.↵
    1. Bruschi M. L.,
    2. de Freitas O.
    Oral bioadhesive drug delivery systems. Drug Dev. Ind. Pharm. 2005, 31 (3), 293–310.
    OpenUrlPubMed
  78. 78.↵
    1. Gandhi R. B.,
    2. Robinson J. R.
    Oral cavity as a site for bioadhesive drug delivery. Adv. Drug Deliv. Rev. 1994, 13 (1–2), 43–74.
    OpenUrl
  79. 79.↵
    1. Rathbone M. J.,
    2. Drummond B. K.,
    3. Tucker I. G.
    The oral cavity as a site for systemic drug delivery. Adv. Drug Deliv. Rev. 1994, 13 (1–2), 1–22.
    OpenUrl
  80. 80.↵
    1. Anders R.,
    2. Merkle H. P.
    Evaluation of laminated mucoadhesive patches for buccal drug delivery. Int. J. Pharm. 1989, 49 (3), 231–240.
    OpenUrl
  81. 81.↵
    1. Khanvilkar K.,
    2. Donovan M. D.,
    3. Flanagan D. R.
    Drug transfer through mucus. Adv. Drug Deliv. Rev. 2001, 48 (2–3), 173–193.
    OpenUrlCrossRefPubMedWeb of Science
  82. 82.↵
    1. Jain A. C.,
    2. Aungst B. J.,
    3. Adeyeye M. C.
    Development and in vivo evaluation of buccal tablets prepared using danazolsulfobutylether 7 β-cyclodextrin (SBE 7) complexes. J. Pharm. Sci. 2002, 91 (7), 1659–1668.
    OpenUrlPubMed
  83. 83.↵
    1. Veuillez F.,
    2. Kalia Y. N.,
    3. Jacques Y.,
    4. Deshusses J.,
    5. Buri P.
    Factors and strategies for improving buccal absorption of peptides. Eur. J. Pharm. Biopharm. 2001, 51 (2), 93–109.
    OpenUrlCrossRefPubMed
  84. 84.↵
    1. de Vries M. E.,
    2. Boddé H. E.,
    3. Verhoef J. C.,
    4. Junginger H. E.
    Developments in buccal drug delivery. Crit. Rev. Ther. Drug Carr. Syst. 1991, 8 (3), 271–303.
    OpenUrlPubMedWeb of Science
  85. 85.↵
    1. Mathiowitz E.,
    2. Chickering D. E. III.,
    3. Lehr C. M.
    1. Lueßen H. L.,
    2. Verhoef J. C.,
    3. de Bore A. G.,
    4. Junginger H. E.,
    5. de Leeuw B. J.,
    6. Borchard G.,
    7. Lehr C. M.
    Multifunctional Polymers for the Peroral Delivery of Peptide Drugs. In Bioadhesive Drug Delivery Systems. Fundamentals, Novel Approaches, and Development; Mathiowitz E., Chickering D. E. III., Lehr C. M. Eds.; Marcel Dekker: New York, 1999; pp 299–339.
  86. 86.↵
    1. Park H.,
    2. Robinson J. R.
    Physicochemical properties of water insoluble polymers important to mucin epithelial adhesion. J. Controlled Release 1985, 2, 47–57.
    OpenUrl
  87. 87.↵
    1. Gennaro A. R.
    1. Rudnic E. M.,
    2. Schwartz J. D.
    Oral Solid Dosage Forms. In Remington: The Science and Practice of Pharmacy, 20th ed.; Gennaro A. R. Ed.; Lippincott Williams & Wilkins: Baltimore, MD, 2000; pp 858–859.
  88. 88.↵
    1. Irache J. M.,
    2. Huici M.,
    3. Konecny M.,
    4. Espuelas S.,
    5. Campanero M. A.,
    6. Arbos P.
    Bioadhesive properties of Gantrez nanoparticles. Molecules 2005, 10 (1), 126–145.
    OpenUrlPubMed
  89. 89.↵
    1. Junginger H. E.,
    2. Hoogstraate J. A.,
    3. Verhoef J. C.
    Recent advances in buccal drug delivery and absorption—in vitro and in vivo studies. J. Controlled Release 1999, 62 (1–2), 149–159.
    OpenUrlCrossRefPubMedWeb of Science
  90. 90.↵
    1. Ramesha B.,
    2. Chary R.,
    3. Vani G.,
    4. Madhusudan R. Y.
    In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm. 1999, 25 (5), 685–690.
    OpenUrlPubMed
  91. 91.↵
    1. Bologna W. J.,
    2. Levine H. L.,
    3. Cartier P.,
    4. de Ziegler D.
    Bioadhesive Progressive Hydration Tablets and Methods of Making and Using the Same. U.S. Patent 6,248,358, August 23, 1999.
  92. 92.↵
    1. Batchelor H.
    Strategies in mucosal-adhesive drug delivery. CRS Newsletter 2005, 22 (1), 4–5.
    OpenUrl
  93. 93.↵
    1. Nafee N. A.,
    2. Ismail F. A.,
    3. Boraie N. A.,
    4. Mortada L. M.
    Mucoadhesive delivery systems. I. Evaluation of mucoadhesive polymers for buccal tablet formulation. Drug Dev Ind. Pharm. 2004, 30 (9), 985–993.
    OpenUrlPubMed
  94. 94.↵
    1. Batchelor H.
    Novel bioadhesive formulations in drug delivery. The Drug Delivery Companies Report 2004, Pharma. Ventures Ltd., Autumn/Winter.
  95. 95.↵
    1. Dowty M. E.,
    2. Knuth K. E.,
    3. Robinson J. R.
    Enzyme characterization studies on the rate-limiting barrier in rabbit buccal mucosa. Int. J. Pharm. 1992, 88 (1–3), 293–302.
    OpenUrl
  96. 96.↵
    1. Mehta M.,
    2. Kemppainen B. W.,
    3. Staffford R. G.
    In vitro penetration of tritium-labelled water (THO) and [3H]PbTx-3 (a red tide toxin) through monkey buccal mucosa and skin. Tox. Lett. 1991, 55 (2), 185–194.
    OpenUrl
  97. 97.↵
    1. Quadros E.,
    2. Cassidy J.,
    3. Gniecko K.,
    4. Le Roy S.
    Buccal and colonic absorption of CGS 16617, a novel ACE inhibitor. J. Controlled Release 1991, 19 (1–3), 77–86.
    OpenUrl
  98. 98.↵
    1. Squier C. A.,
    2. Hall B. K.
    The permeability of skin and oral mucosa to water and horseradish peroxidase as related to the thickness of the permeability barrier. J. Invest. Dermatol. 1985, 84 (3), 176–179.
    OpenUrlPubMedWeb of Science
  99. 99.↵
    1. Hoogstraate A. J.,
    2. Cullander C.,
    3. Nagelkerke J. F.,
    4. Verhoel J.,
    5. Junginger H. E.,
    6. Bodde H. E.
    Diffusion rates and transport pathways of FITC-labelled model compounds through buccal epithelium. Proceed. Int. Symp. Control. Rel. Bioact. Mater. 1993, 20, 234–235.
    OpenUrl
  100. 100.↵
    1. Collins P.,
    2. Laffoon J.,
    3. Squier C. A.
    Comparative study of porcine oral epithelium. J. Dent. Res. 1981, 60, 543.
    OpenUrl
  101. 101.↵
    1. Reddy P. C.,
    2. Rao Y. M.
    A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. DARU Journal of Pharmaceutical Sciences 2011, 19 (6), 385–403.
    OpenUrlPubMed
  102. 102.↵
    1. Reddy P. C.,
    2. Ramesh G.,
    3. Vishnu Y. V.,
    4. Kumar Y. S.,
    5. Rao Y. M.
    Development of bilayered mucoadhesive patches for buccal delivery of felodipine: in vitro and ex vivocharacterization. Curr. Trends Biotech. Pharm. 2010, 4 (2), 673–683.
    OpenUrl
  103. 103.↵
    1. Ghebre-Sellassie I.,
    2. Martin C.
    1. Luker K.
    Single-Screw Extrusion and Screw Design. In Pharmaceutical Extrusion Technology. Drugs and the Pharmaceutical Sciences; Ghebre-Sellassie I., Martin C. Eds.; Marcel Dekker: New York, 2003; Vol. 133, pp 39–68.
    OpenUrl
  104. 104.↵
    1. Ndindayino F.,
    2. Henrist D.,
    3. Kiekens F.,
    4. Van den Mooter G.,
    5. Vervaet C.,
    6. Remon J. P.
    Direct compression properties of melt-extruded isomalt. Int. J. Pharm. 2002, 235 (1–2), 149–151.
    OpenUrlPubMed
  105. 105.↵
    1. Lee J.,
    2. Kellaway I. W.
    Buccal permeation of (D-Ala2, DLeu5) enkephalin from liquid crystalline phases of glyceryl monooleate. Int. J. Pharm. 2000, 195, 35–38.
    OpenUrlPubMed
  106. 106.↵
    1. Jug M.,
    2. Becirevic-Lacan M.
    Influence of hydroxypropyl-B-cyclodextrin complexation on piroxicam release from buccoadhesive tablets. Eur. J. Pharm. Sci. 2004, 21, 251–260.
    OpenUrlPubMed
  107. 107.↵
    1. Dowty M. E.,
    2. Knuth K. E.,
    3. Irons B. K.,
    4. Robinson J. R.
    Transport of thyrotropin releasing hormone in rabbit buccal mucosa in vitro. Pharm. Res. 1992, 9, 1113–1122.
    OpenUrlPubMed
  108. 108.↵
    1. Hosny E. A.,
    2. Elkheshen S. A.,
    3. Saleh S. I.
    Buccoadhesive tablets for insulin delivery: in-vitro and in-vivo studies. Boll. Chim. Farm. 2002, 141, 210–217.
    OpenUrlPubMed
  109. 109.↵
    1. Nakane S.,
    2. Kakumoto M.,
    3. Yukimatsu K.,
    4. Chien Y. W.
    Oramucosal delivery of LHRH: pharmacokinetic studies of controlled and enhanced transmucosal permeation. Pharm. Dev. Technol. 1996, 20 (3), 251–259.
    OpenUrl
  110. 110.↵
    1. Taylan B.,
    2. Capan Y.,
    3. Guven O.,
    4. Kes S.,
    5. Hincal A. A.
    Design and evaluation of sustained release and buccal adhesive propronolol hydrochloride tablets. J. Controlled Release 1996, 38 (1), 11–20.
    OpenUrl
  111. 111.↵
    1. Lesch C. A.,
    2. Squier C. A.,
    3. Cruchley A.,
    4. Williams D. M.,
    5. Speight P.
    The permeability of human oral mucosa and skin to water. J. Dent. Res. 1989, 68, 1345–1349.
    OpenUrlAbstract/FREE Full Text
  112. 112.↵
    1. Beckett A. H.,
    2. Triggs E. J.
    Buccal absorption of basic drugs and its application as an in vivo model of passive drug transfer through lipid membranes. J. Pharm. Pharmacol. 1967, 19, 31S–41S.
    OpenUrlPubMed
  113. 113.↵
    1. Benes L.,
    2. Claustrat B.,
    3. Horriere F.
    Transmucosal, oral controlled-release, transdermal drug administration in human subjects: A crossover study with melatonin. J. Pharm. Sci. 1997, 86, 1115–1119.
    OpenUrlCrossRefPubMedWeb of Science
  114. 114.↵
    1. McQuinn R. L.,
    2. Kvam D. C.,
    3. Maser M. J.,
    4. Miller A. L.,
    5. Oliver A.
    Sustained oral mucosal delivery in human volunteers of buprenorphine from thin non-erodingmucoadhesive polymeric disks. J. Controlled Release 1995, 34, 243–250.
    OpenUrl
  115. 115.↵
    1. Jain N. K.
    Controlled Release and Novel Drug Delivery, 1st ed.; CBS Publishers and Distributors: New Delhi, 1997; pp 353–370.
  116. 116.↵
    1. Sonani N. G.,
    2. Hiremath S. P.,
    3. Dasankoppa F. S.,
    4. Jamakandi V. G.,
    5. Steenivas S. A.
    Design and evaluation of gastroretentive mucoadhesive cephalexin tablets. Pharm. Dev. Technol. 2010, 15 (2), 178–183.
    OpenUrlPubMed
  117. 117.↵
    1. Gupta A.,
    2. Garg S.,
    3. Khar R. K.
    Measurement of bioadhesive strength of mucoadhesive buccal tablets: design of an in vitro assembly. Indian Drugs 1992, 30 (4), 152–155.
    OpenUrl
  118. 118.↵
    1. Santos C. A.,
    2. Jacob J. S.,
    3. Hertzog B. A.,
    4. Carino G. P.,
    5. Mathiowitz E.
    Methods and Compositions for Enhancing the Bioadhesive Properties of Polymers Using Organic Excipients. U.S. Patent 6,156,348, December 5, 2000.
  119. 119.↵
    1. Mathiowitz E.,
    2. Chickering D. E.,
    3. Lehr C. M.
    1. Hertzog B. A.,
    2. Mathiowitz E.
    Novel Magnetic Technique ToMeasure Bioadhesion. In Bioadhesive Drug Delivery Systems—Fundamentals Novel Approaches and Development; Mathiowitz E., Chickering D. E., Lehr C. M. Eds.; Marcel Dekker: New York, 1999; pp 147–171.
  120. 120.↵
    1. Swarbrick J.,
    2. Boylan J. C.
    1. Kamath K. R.,
    2. Park K.
    Mucosal Adhesive Preparations. In Encyclopedia of Pharmaceutical Technology; Swarbrick J., Boylan J. C. Eds.; Marcel Dekker: New York, 1994; Vol. 10, pp 133–163.
    OpenUrlFREE Full Text
  121. 121.↵
    1. Mikos A. G.,
    2. Peppas N. A.
    Bioadhesive analysis of controlled release systems. IV. An experimental method for testing the adhesion of microparticles with mucus. J. Controlled Release. 1990, 2 (2), 31–37.
    OpenUrl
  122. 122.↵
    1. Riley R. G.,
    2. Smart J. D.,
    3. Tsibouklis J.,
    4. Dettmar P. W.,
    5. Hampson F.,
    6. Davis J. A.,
    7. Kelly G.,
    8. Wilber R. W.
    An investigation of mucus/polymer rheological synergism using synthesized and characterized poly (acrylic acid). Int. J. Pharm. 2001, 21 (7), 87–100.
    OpenUrl
  123. 123.↵
    1. Park K.
    A new approach to study mucoadhesion: Colloidal gold staining. Int J. Pharm. 1989, 53, 209–217.
    OpenUrl
  124. 124.↵
    1. Hassan E. E.,
    2. Gallo J. M.
    Simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res. 1990, 7, 491–498.
    OpenUrlPubMed
  125. 125.↵
    1. Park K.,
    2. Robinson J. R.
    Bioadhesive polymers as platforms for oral controlled drug delivery: method to study bioadhesion. Int. J. Pharm. 1984, 19, 107–1279.
    OpenUrlCrossRefWeb of Science
  126. 126.↵
    1. Mathiowitz E.
    1. Mathiowitz E.,
    2. Chickering D.,
    3. Jacob J. S.,
    4. Santos C.
    Bioadhesive Drug Delivery Systems. In Encyclopedia of Controlled Drug Delivery; Mathiowitz E. Ed.; Wiley: New York, 1999; Vol. 1, pp 9–44.
    OpenUrl
  127. 127.↵
    1. Khurana R.,
    2. Ahuja A.,
    3. Khar R. K.
    Development and evaluation of mucoadhesive films of miconazole nitrate. Indian J. Pharm. Sci. 2000, 60, 449–453.
    OpenUrl
  128. 128.↵
    1. Nafee N. A.,
    2. Boraie N. A.,
    3. Ismail F. A.,
    4. Mortada L. M.
    Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharm. 2003, 53, 199–212.
    OpenUrlPubMed
  129. 129.↵
    1. Shivanand K.,
    2. Raju S. A.,
    3. Nizamuddin S.,
    4. Jayakar B.
    In vivo bioavailability studies of sumatriptan succinate buccal tablets. DARU J. Pharm. Sci. 2011, 19 (3), 224–230.
    OpenUrl
  130. 130.↵
    1. Palem C. R.,
    2. Gannu R.,
    3. Yamsani S. K.,
    4. Yamsani V. V.,
    5. Yamsani M. R.
    Development of bioadhesive buccal tablets for felodipine and pioglitazone in combined dosage form: in vitro, ex vivo, and in vivocharacterization. Drug Del. 2011, 18 (5) 344–352.
    OpenUrl
  131. 131.↵
    1. Bottenberg P.,
    2. Cleymaet R.,
    3. Muynek C. D.,
    4. Remon J. P.,
    5. Coomans D.,
    6. Slop D.
    Development and testing of bioadhesive, fluoride containing slow-release tablets for oral use. J. Pharm. Pharmacol. 1991, 43, 457–464.
    OpenUrlPubMed
  132. 132.↵
    1. Nakamura F.,
    2. Ohta R.,
    3. Machida Y.,
    4. Nagai T.
    In vitro and in vivonasal mucoadhesion of water-soluble polymers. Int. J. Pharm. 1996, 134, 173–181.
    OpenUrl
  133. 133.↵
    1. Shermer A.,
    2. Amicji B.,
    3. Trau H.,
    4. Nathansohn N.,
    5. Mizrahi B.,
    6. Domb A. J.
    Efficacy of a mucoadhesice patch compared with an oral solution for treatment of aphthous stomatitis. Drugs R. D. 2008, 9 (1), 29–35.
    OpenUrlPubMed
  134. 134.↵
    1. Donnelly R. F.,
    2. McCarron P. A.,
    3. Tunney M. M.,
    4. Woolfson A. D.
    Potential of photodynamic therapy in treatment of fungal infections of the mouth. Design and characterization of a mucoadhesive patch containing toluidine blue. J. Photochem. Photobiol.B 2007, 86 (1), 59–69.
    OpenUrl
  135. 135.↵
    1. Lee J.,
    2. Kellaway I. W.
    Buccal permeation of (D-Ala2, DLeu5) enkephalin from liquid crystalline phases of glyceryl monooleate. Int. J. Pharm. 2000, 195, 35–38.
    OpenUrlPubMed
  136. 136.↵
    1. Modi G.,
    2. Mihic M.,
    3. Lewin A.
    Evolving role of oral insulin in the treatment of diabetes using a novel rapidmist system. Diabetes Metab. Res. Rev. 2002, 18 (Suppl. 1), S38–S42.
    OpenUrlCrossRefPubMed
  137. 137.↵
    1. Yang T. Z.,
    2. Wang X. T.,
    3. Yan X. Y.,
    4. Zhang Q.
    Phospholipid deformable vesicles for buccal delivery of insulin. Chem. Pharm. Bull. 2002, 50 (6), 749–753.
    OpenUrlPubMed
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PDA Journal of Pharmaceutical Science and Technology: 66 (5)
PDA Journal of Pharmaceutical Science and Technology
Vol. 66, Issue 5
September/October 2012
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Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems
Dattatraya Manohar Shinkar, Avinash Sridhar Dhake, Chitral Mallikarjuna Setty
PDA Journal of Pharmaceutical Science and Technology Sep 2012, 66 (5) 466-500; DOI: 10.5731/pdajpst.2012.00877

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Drug Delivery from the Oral Cavity: A Focus on Mucoadhesive Buccal Drug Delivery Systems
Dattatraya Manohar Shinkar, Avinash Sridhar Dhake, Chitral Mallikarjuna Setty
PDA Journal of Pharmaceutical Science and Technology Sep 2012, 66 (5) 466-500; DOI: 10.5731/pdajpst.2012.00877
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  • Article
    • Abstract
    • Introduction
    • Advantages of the Mucoadhesive Buccal Drug Delivery System
    • Limitations of the Mucoadhesive Buccal Drug Delivery System
    • Anatomy and Structure of the Oral Cavity
    • Composition of Mucus Layer
    • Functions of the Mucus Layer
    • Structure of the Oral Mucosa
    • Buccal Absorption
    • Assessing Drug Permeation through the Buccal Mucosa
    • Buccal Penetration Enhancers (31, 32)
    • Classification and Examples of Membrane Permeation Enhancers
    • Mechanism of Permeation Enhancers
    • Bioadhesion/Mucoadhesion
    • Mechanism of Mucoadhesion/Bioadhesion
    • Theories on Mucoadhesion/Bioadhesion
    • Factors Affecting Mucoadhesion
    • Buccal Mucoadhesive Polymers
    • Ideal Characteristics of Buccal Mucoadhesive Polymers (24)
    • New-Generation Mucoadhesive Polymers
    • Buccal Mucoadhesive Dosage Forms
    • General Considerations in Designing Dosage Forms
    • Approaches to the Use of Mucoadhesive Formulations
    • Relevant Mucoadhesive Buccal Dosage Forms
    • Evaluation of Mucoadhesive Buccal Drug Delivery Systems
    • In Vitro Techniques
    • Work of Adhesion
    • Other In Vitro Methods
    • In Vivo Techniques
    • Method
    • Ex Vivo Residence Time
    • In Vivo Residence Time
    • Current Market Status of Buccal Drug Delivery Systems
    • Conclusion
    • Conflict of Interest Declaration
    • Acknowldgements
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

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Keywords

  • Mucoadhesion
  • Oral mucosa
  • Buccal route
  • Penetration enhancer
  • Therapeutic performance

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