Inhibiting Sterilization-Induced Oxidation of Large Molecule Therapeutics Packaged in Plastic Parenteral Vials

Jeffrey R. Vieregg; Steven J. Martin; Adam P. Breeland; Christopher M. Weikart; Matthew V. Tirrell

doi:10.5731/pdajpst.2017.008011

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Inhibiting Sterilization-Induced Oxidation of Large Molecule Therapeutics Packaged in Plastic Parenteral Vials

Jeffrey R. Vieregg, Steven J. Martin, Adam P. Breeland, Christopher M. Weikart and Matthew V. Tirrell

PDA Journal of Pharmaceutical Science and Technology January 2018, 72 (1) 35-43; DOI: https://doi.org/10.5731/pdajpst.2017.008011

Jeffrey R. Vieregg

1Institute for Molecular Engineering, University of Chicago, Chicago, IL;

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Steven J. Martin

2SiO Medical Products, Auburn, AL; and

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Adam P. Breeland

2SiO Medical Products, Auburn, AL; and

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Christopher M. Weikart

2SiO Medical Products, Auburn, AL; and

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Matthew V. Tirrell

1Institute for Molecular Engineering, University of Chicago, Chicago, IL;

3Institute for Molecular Engineering, Argonne National Laboratory, Argonne, IL

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For correspondence: mtirrell@uchicago.edu

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vol. 72 no. 1 35-43

DOI

https://doi.org/10.5731/pdajpst.2017.008011

PubMed

28928291

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online January 30, 2018.

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previous version (September 19, 2017 - 05:22).
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Jeffrey R. Vieregg1,
Steven J. Martin2,
Adam P. Breeland2,
Christopher M. Weikart2 and
Matthew V. Tirrell1,3,*

¹Institute for Molecular Engineering, University of Chicago, Chicago, IL;
²SiO₂ Medical Products, Auburn, AL; and
³Institute for Molecular Engineering, Argonne National Laboratory, Argonne, IL

↵*Corresponding Author: University of Chicago, ERC 299C, 5640 S. Ellis Ave., Chicago, IL 60637. Telephone: 773-834-2001; e-mail: mtirrell{at}uchicago.edu

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Inhibiting Sterilization-Induced Oxidation of Large Molecule Therapeutics Packaged in Plastic Parenteral Vials

Jeffrey R. Vieregg, Steven J. Martin, Adam P. Breeland, Christopher M. Weikart, Matthew V. Tirrell

PDA Journal of Pharmaceutical Science and Technology Jan 2018, 72 (1) 35-43; DOI: 10.5731/pdajpst.2017.008011

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Inhibiting Sterilization-Induced Oxidation of Large Molecule Therapeutics Packaged in Plastic Parenteral Vials

Jeffrey R. Vieregg, Steven J. Martin, Adam P. Breeland, Christopher M. Weikart, Matthew V. Tirrell

PDA Journal of Pharmaceutical Science and Technology Jan 2018, 72 (1) 35-43; DOI: 10.5731/pdajpst.2017.008011

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Keywords

Primary containers
oxidation
permeation
Sterilization
Teriparatide
Erythropoietin

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