Failure of Glass Tubing Vials during Lyophilization

David R. Machak; Gary L. Smay

doi:10.5731/pdajpst.2017.008276

Research ArticleResearch

Failure of Glass Tubing Vials during Lyophilization

David R. Machak and Gary L. Smay

PDA Journal of Pharmaceutical Science and Technology January 2019, 73 (1) 30-38; DOI: https://doi.org/10.5731/pdajpst.2017.008276

David R. Machak

American Glass Research, a Division of AGR International, Inc., 603 Evans City Road, Butler, PA, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: dmachak@agrintl.com

Gary L. Smay

American Glass Research, a Division of AGR International, Inc., 603 Evans City Road, Butler, PA, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
References
Info & Metrics
PDF

Article Information

vol. 73 no. 1 30-38

DOI

https://doi.org/10.5731/pdajpst.2017.008276

PubMed

30361283

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online February 1, 2019.

Article Versions

previous version (October 25, 2018 - 06:38).
You are viewing the most recent version of this article.

Author Information

David R. Machak* and
Gary L. Smay

American Glass Research, a Division of AGR International, Inc., 603 Evans City Road, Butler, PA, USA.

↵* Corresponding Author: American Glass Research, a Division of AGR International, Inc., 603 Evans City Road, Butler, PA 16001; E-mail: dmachak{at}agrintl.com

View Full Text

Cited By...

7 Citations
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Mannitol as an Excipient for Lyophilized Injectable Formulations

Seema Thakral, Jayesh Sonje, Bhushan Munjal, Bakul Bhatnagar, Raj Suryanarayanan

Journal of Pharmaceutical Sciences 2023 112 1
Best Practices and Guidelines (2022) for Scale-up and Technology Transfer in Freeze Drying Based on Case Studies. Part 2: Past Practices, Current Best Practices, and Recommendations

Serguei Tchessalov, Evgenyi Shalaev, Bakul Bhatnagar, Steven Nail, Alina Alexeenko, Feroz Jameel, Jayasree Srinivasan, Michael Dekner, Ekneet Sahni, Stefan Schneid, Petr Kazarin, Orla McGarvey, Bert Van Meervenne, Vaibhav Kshirsagar, Paritosh Pande, Jens Philipp, Greg Sacha, Ke Wu, Joseph Azzarella, Gayathri Shivkumar, Shreyas Bhatt, Shyam B. Mehta

AAPS PharmSciTech 2023 24 4
A Regulatory Perspective on Manufacturing Processes Pertaining to Lyophilized Injectable Products

Steve Y. Rhieu, David D. Anderson, Kumar Janoria

The AAPS Journal 2020 22 5
Vial Breakage in Lyophilization- Case Studies from Commercial Manufacturing and Laboratory Studies

Ekneet K. Sahni, Jim A. Searles, Mark Nachtigall, Eric Owen, Dina Lyne

Journal of Pharmaceutical Sciences 2023 112 4
Freeze Drying and Vial Breakage: Misconceptions, Root Causes and Mitigation Strategies for the Pharmaceutical Industry

Xin Jin, David O'Grady, Richard P. Affleck, Stefano Martini, Atul Saluja

Journal of Pharmaceutical Sciences 2024 113 5
Principles and Practices of Lyophilization in Product Development and Manufacturing

Robert Ovadia, Phillippe Lam, Holger Roehl, Renaud Janssen, Roger Asselta

2023 59
Principles and Practices of Lyophilization in Product Development and Manufacturing

Jim A. Searles, Ekneet K. Sahni

2023 59

PreviousNext

In This Issue

PDA Journal of Pharmaceutical Science and Technology

Vol. 73, Issue 1

January/February 2019

Table of Contents
Index by Author

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Failure of Glass Tubing Vials during Lyophilization

Message Subject (Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology

Message Body (Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Math question * 5 + 9 =

Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.

Citation Tools

Failure of Glass Tubing Vials during Lyophilization

David R. Machak, Gary L. Smay

PDA Journal of Pharmaceutical Science and Technology Jan 2019, 73 (1) 30-38; DOI: 10.5731/pdajpst.2017.008276

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Failure of Glass Tubing Vials during Lyophilization

David R. Machak, Gary L. Smay

PDA Journal of Pharmaceutical Science and Technology Jan 2019, 73 (1) 30-38; DOI: 10.5731/pdajpst.2017.008276

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Jump to section

Article
Figures & Data
References
Info & Metrics
PDF

No related articles found.

PubMed
Google Scholar

Cited By...

No citing articles found.

Google Scholar

Keywords

Borosilicate glass
fracture diagnosis
Fracture patterns
Lyophilization
Thermal shock
Internal force

Main menu

User menu

Search

Failure of Glass Tubing Vials during Lyophilization

Article Information

Article Versions

Author Information

Cited By...

In This Issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Keywords

Readers

Author/Reviewer Information

Parenteral Drug Association, Inc.