Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleResearch

Failure of Glass Tubing Vials during Lyophilization

David R. Machak and Gary L. Smay
PDA Journal of Pharmaceutical Science and Technology January 2019, 73 (1) 30-38; DOI: https://doi.org/10.5731/pdajpst.2017.008276
David R. Machak
American Glass Research, a Division of AGR International, Inc., 603 Evans City Road, Butler, PA, USA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: dmachak@agrintl.com
Gary L. Smay
American Glass Research, a Division of AGR International, Inc., 603 Evans City Road, Butler, PA, USA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Jiang G. E.,
    2. Akers M.
    Mechanistic Studies of Glass Vial Breakage for Frozen Formulations I. PDA J. Pharm. Sci. Technol. 2007, 61 (6), 441–451.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Williams N. A.,
    2. Guglielmo J.
    Thermal Mechanical Analysis of Frozen Solutions of Mannitol and Some Related Stereoisomers. PDA J. Pharm. Sci. Technol. 1993, 47 (3), 119–123.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Chow E. J.,
    2. Kitaguchi B.,
    3. Trier M.
    Effects of Subzero Temperature Exposure and Supercooling on Glass Vial Breakage. PDA J. Pharm. Sci. Technol. 2012, 66 (1), 55–62.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Milton N.,
    2. Gopalrathnam G.,
    3. Craig G. D.,
    4. Mishra D. S.,
    5. Roy M. L.,
    6. Yu L.
    Vial Breakage during Freeze-Drying: Crystallization of Sodium Chloride in Sodium Chloride-Sucrose Frozen Aqueous Solutions. J. Pharm. Sci. 2007, 96 (7), 1848–1853.
    OpenUrlPubMed
  5. 5.↵
    1. Quinn G. D.
    Fractography of Ceramics and Glasses; Special Publication 960-16e2; National Institute of Standards and Technology: 2007; Chapters 4, 5, 7.
  6. 6.↵
    ASTM C1678–10: Standard Practice for Fractographic Analysis of Fracture Mirror Sizes in Ceramics and Glasses, 3 2010.
  7. 7.↵
    1. Bradt R. C.,
    2. Tessler R. E.
    Fractography of Glass; Plenum Press: 1994; pp 207–252.
  8. 8.↵
    1. Lomax J.
    Fracture Analysis as an Aid to Quality Improvement. Glass, 3, 1972, 1–6.
  9. 9.↵
    1. Mecholsky J. J.,
    2. Rice R. W.,
    3. Freiman S. W.
    Predictions of Fracture Energy and Flaw Size in Glasses from Measurements of Mirror Size. J. Am. Cer. Soc. 1974, 57 (10), 440.
    OpenUrl
  10. 10.↵
    1. Shand E. B.
    Glass Engineering Handbook; McGraw-Hill Book Co.: New York, 1958; p 112.
  11. 11.↵
    1. Mould R. E.,
    2. Southwick R. D.
    Strength and Static Fatigue of Abraded Glass Under Controlled Ambient Conditions: II Effect of Various Abrasions and the Universal Fatigue Curve. J. Am. Cer. Soc. 1958, 42 (12), 582.
    OpenUrl
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 73 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 73, Issue 1
January/February 2019
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Failure of Glass Tubing Vials during Lyophilization
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
10 + 5 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Failure of Glass Tubing Vials during Lyophilization
David R. Machak, Gary L. Smay
PDA Journal of Pharmaceutical Science and Technology Jan 2019, 73 (1) 30-38; DOI: 10.5731/pdajpst.2017.008276

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Failure of Glass Tubing Vials during Lyophilization
David R. Machak, Gary L. Smay
PDA Journal of Pharmaceutical Science and Technology Jan 2019, 73 (1) 30-38; DOI: 10.5731/pdajpst.2017.008276
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Discussion
    • Laboratory Tests
    • Results of Laboratory Tests
    • Conclusions
    • Conflict of Interest Declaration
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Analysis of Virus Clearance for Biotechnology Manufacturing Processes from Early to Late Phase Development
  • Coring and Fragmentation of Elastomeric Needle Shield in a Pre-Filled Syringe
  • Worldwide Regulatory Reliance: Results of an Executed Chemistry, Manufacturing, and Control Post-Approval Change Pilot
Show more Research

Similar Articles

Keywords

  • Borosilicate glass
  • fracture diagnosis
  • Fracture patterns
  • Lyophilization
  • Thermal shock
  • Internal force

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire