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Research ArticleResearch

Freezing Time Prediction of Biologic Formulated Drug Substance Using the Plank Model

Mostafa Nakach, Firas Bahloul, StÉphanie Greco, Jean-RenÉ Authelin, Otmar Klingler and Cathrin Bernhardt
PDA Journal of Pharmaceutical Science and Technology January 2021, 75 (1) 24-32; DOI: https://doi.org/10.5731/pdajpst.2019.011247
Mostafa Nakach
1Sanofi R&D, 1, Impasse des Ateliers, 94403 Vitry sur Seine, France;
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  • For correspondence: mostafa.nakach@sanofi.com
Firas Bahloul
227 Avenue d'Alsace Lorraine 93130 Noisy le Sec, France; and
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StÉphanie Greco
1Sanofi R&D, 1, Impasse des Ateliers, 94403 Vitry sur Seine, France;
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Jean-RenÉ Authelin
1Sanofi R&D, 1, Impasse des Ateliers, 94403 Vitry sur Seine, France;
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Otmar Klingler
3Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, D-65926 Frankfurt am Main, Germany
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Cathrin Bernhardt
3Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, D-65926 Frankfurt am Main, Germany
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Article Information

vol. 75 no. 1 24-32
DOI 
https://doi.org/10.5731/pdajpst.2019.011247
PubMed 
32817319

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online February 22, 2021.

Article Versions

  • previous version (August 14, 2020 - 07:58).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© PDA, Inc. 2021

Author Information

  1. Mostafa Nakach1,*,
  2. Firas Bahloul2,
  3. StÉphanie Greco1,
  4. Jean-RenÉ Authelin1,
  5. Otmar Klingler3 and
  6. Cathrin Bernhardt3
  1. 1Sanofi R&D, 1, Impasse des Ateliers, 94403 Vitry sur Seine, France;
  2. 227 Avenue d'Alsace Lorraine 93130 Noisy le Sec, France; and
  3. 3Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, D-65926 Frankfurt am Main, Germany
  1. ↵* Corresponding Author: Sanofi R&D, 1, Impasse des Ateliers 94403 Vitry sur Seine, France; Telephone: +33 1 58 93 21 96; Fax: + 33 1 58 93 32 10; E-mail: mostafa.nakach@sanofi.com
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PDA Journal of Pharmaceutical Science and Technology: 75 (1)
PDA Journal of Pharmaceutical Science and Technology
Vol. 75, Issue 1
January/February 2021
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Freezing Time Prediction of Biologic Formulated Drug Substance Using the Plank Model
Mostafa Nakach, Firas Bahloul, StÉphanie Greco, Jean-RenÉ Authelin, Otmar Klingler, Cathrin Bernhardt
PDA Journal of Pharmaceutical Science and Technology Jan 2021, 75 (1) 24-32; DOI: 10.5731/pdajpst.2019.011247
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Keywords

  • Freezing
  • Kinetics
  • Cryo-concentration
  • Crystallization
  • Heat transfer coefficient
  • Plank modeling

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Freezing Time Prediction of Biologic Formulated Drug Substance Using the Plank Model
Mostafa Nakach, Firas Bahloul, StÉphanie Greco, Jean-RenÉ Authelin, Otmar Klingler, Cathrin Bernhardt
PDA Journal of Pharmaceutical Science and Technology Jan 2021, 75 (1) 24-32; DOI: 10.5731/pdajpst.2019.011247

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