Abstract
The solubility of the drug is a significant aspect to be considered during manufacturing of pharmaceutical products. Poor aqueous solubility of drugs imparts depleted bioavailability. In this regard, several techniques are available for enhancing drug solubility or dissolution. However, only few of them are scalable and industrially applicable. Hot-melt extrusion (HME) is one such technique that has been widely used in the industry. It is a single-step, continuous manufacturing, and scalable method that has proved successful in improving the solubility of poorly soluble drugs. This review highlights the numerous pharmaceutical applications of HME, such as formulations of sterile implants, taste masking of unpleasant drugs, cocrystallization, salt formation, sustained and controlled release formulations, etc. It also describes various hydrophilic and hydrophobic carriers utilized in HME. This review also briefly discusses the recent advances in HME and gives an update on the currently available marketed products. The opportunities and challenges in future development of pharmaceutical products by HME technique are also discussed.
- © PDA, Inc. 2021
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In This Issue
Jump to section
- Article
- Abstract
- 1. Introduction
- 2. Solubility Enhancement by HME Technique
- 3. HME Processing Aspects
- 4. HME Equipment
- 5. Advantages of HME over Conventional Techniques for Solubility Enhancement
- 6. Polymeric Carriers in HME for Solubility Enhancement
- 7. Quality-by-Design Approach in the HME Technique
- 8. Application of HME in Different Dosage Forms
- 9. Marketed Products
- 10. Concluding Remarks and Future Perspective
- Conflict of Interest Declaration
- Acknowledgment
- References
- Figures & Data
- References
- Info & Metrics
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