Hot-Melt Extrusion: An Emerging Technique for Solubility Enhancement of Poorly Water-Soluble Drugs

Amit Chivate; Atul Garkal; Namdev Dhas; Tejal Mehta

doi:10.5731/pdajpst.2019.011403

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Hot-Melt Extrusion: An Emerging Technique for Solubility Enhancement of Poorly Water-Soluble Drugs

Amit Chivate, Atul Garkal, Namdev Dhas and Tejal Mehta

PDA Journal of Pharmaceutical Science and Technology July 2021, 75 (4) 357-373; DOI: https://doi.org/10.5731/pdajpst.2019.011403

Amit Chivate

1Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India;

3Roquette India Ltd., Area Market Manager, India, South East Asia, Middle East Africa and Australia & New Zealand

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Atul Garkal

1Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India;

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Namdev Dhas

1Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India;

2SRES Sanjivani College of Pharmaceutical Education and Research, Sahajanandnagar, Singnapur, Kopargaon, Ahmednagar, Maharashtra 423603, India; and

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Tejal Mehta

1Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India;

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For correspondence: tjshah3@gmail.com

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vol. 75 no. 4 357-373

DOI

https://doi.org/10.5731/pdajpst.2019.011403

PubMed

33608469

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Parenteral Drug Association (PDA)

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1079-7440

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1948-2124

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Published online August 3, 2021.

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previous version (February 19, 2021 - 05:13).
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Amit Chivate^1,³,
Atul Garkal¹,
Namdev Dhas^1,² and
Tejal Mehta¹,*

¹Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India;
²SRES Sanjivani College of Pharmaceutical Education and Research, Sahajanandnagar, Singnapur, Kopargaon, Ahmednagar, Maharashtra 423603, India; and
³Roquette India Ltd., Area Market Manager, India, South East Asia, Middle East Africa and Australia & New Zealand

↵* Corresponding Author: Institute of Pharmacy, Nirma University, S.G. Hwy., Chharodi Ahmedabad 382481, Gujrat, India; Telephone: +919879357584; E-mail: tjshah3{at}gmail.com

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Hot-Melt Extrusion: An Emerging Technique for Solubility Enhancement of Poorly Water-Soluble Drugs

Amit Chivate, Atul Garkal, Namdev Dhas, Tejal Mehta

PDA Journal of Pharmaceutical Science and Technology Jul 2021, 75 (4) 357-373; DOI: 10.5731/pdajpst.2019.011403

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Hot-Melt Extrusion: An Emerging Technique for Solubility Enhancement of Poorly Water-Soluble Drugs

Amit Chivate, Atul Garkal, Namdev Dhas, Tejal Mehta

PDA Journal of Pharmaceutical Science and Technology Jul 2021, 75 (4) 357-373; DOI: 10.5731/pdajpst.2019.011403

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Keywords

Solubility and dissolution enhancement
Hot-melt extrusion
Solid-dispersion
Poorly water-soluble drugs

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