Article Figures & Data
Figures
- Figure 1
System architecture for the BSB System. IP, industrial protocol; HMI, human machine interface; OPC UA, Open Platform Communications Unified Architecture; OWS, operator workstation; SQL, structured query language.
- Figure 2
Buffer composition and flow rates for typical monoclonal antibody process.
- Figure 3
BSB System flow diagram. C, conductivity; F, flow; P, pressure; T, temperature; WFI, water for injection.
- Figure 4
General system architecture of the BSB System. HMI, human machine interface; OPC DA/UA, Open Platform Communications Data Access/Unified Architecture; SQL, structured query language; WFI, water for injection.
- Figure 5
Example buffer run: 50 mM Sodium Acetate, pH 3.5. WFI, water for injection.
- Figure 6
Coefficient of Variation of pH (%CV). RSD, relative standard deviation.
- Figure 7
Coefficient of Variation of Conductivity (%CV). RSD, relative standard deviation.
- Figure 8
Offline/Online pH comparison.
- Figure 9
Offline/Online conductivity comparison.
- Figure 10
Performance of stock pumps vs flow rate.
- Figure 11
Performance of water for injection (WFI) pump vs flow rate.
- Figure 12
Pre-collect startup time.
- Figure 13
Stock wasted to drain by pump for specific stocks in buffer batches.
- Figure 14
Dilution Factor (mass batch/mass stocks).
- Figure 15
ÄKTA connected buffer production. WFI, water for injection.
- Figure 16
Equipment occupancy chart for various modes of buffer preparation (generated using SchedulePro V9.100).
- Figure 17
Cost comparison of buffer preparation by different methods. WFI, water for injection.
Tables
Pump PU-100 PU-200 PU-300 PU-400 Pump Quattroflow™ 1200HT 3° cam (Low Flow) Quattroflow™ 1200HT 5° cam (High Flow) LEWA Ecodos® 5 mm (Low Flow) LEWA Ecodos® 7.5 mm (High Flow) Optimal Flow (Kg/min)1 0.4–12 0.4–20 0.4–3 0.4–15 Theoretical Dilution Ratio Range2 3.3–100 2–100 13.3–100 2.7–100 Stock 1 0.2 M NaH2PO4 1M NaCl 0.15 M Na Acetate 0.4M Na2HPO4 Stock 2 1 M Acetic Acid 3M (NH4)2SO4 1 M Tris HCl 1M NaOH Stock 3 — — — 0.3 M Na Acetate Study range (Kg/min)3 0.52–3.3 0.7–9.4 0.6–2.8 2.7–9.4
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