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Research ArticleResearch

Correlating GC/MS Relative Response Factors to Analyte’s Physicochemical and Chromatographic Properties to Facilitate the Quantitation of Organic Extractables and Leachables in Non-Targeted Analysis (NTA). Concepts and Empirical Considerations

Dennis Jenke, Piet Christiaens, Philippe Verlinde, Jan Baeten and Jean-Marie Beusen
PDA Journal of Pharmaceutical Science and Technology November 2024, 78 (6) 625-642; DOI: https://doi.org/10.5731/pdajpst.2023.012884
Dennis Jenke
Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium
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  • For correspondence: dennisjenke@triadscientificsolutions.com
Piet Christiaens
Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium
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Philippe Verlinde
Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium
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Jan Baeten
Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium
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Jean-Marie Beusen
Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium
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Article Information

vol. 78 no. 6 625-642
DOI 
https://doi.org/10.5731/pdajpst.2023.012884
PubMed 
39725482

Published By 
Parenteral Drug Association (PDA)
Print ISSN 
1079-7440
Online ISSN 
1948-2124
History 
  • Published online December 26, 2024.

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  • previous version (February 22, 2024 - 06:35).
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© PDA, Inc. 2024

Author Information

  1. Dennis Jenke*,
  2. Piet Christiaens,
  3. Philippe Verlinde,
  4. Jan Baeten and
  5. Jean-Marie Beusen
  1. Nelson Labs, Romeinsestraat 12, 3001 Heverlee, Belgium
  1. ↵* Corresponding Author: Triad Scientific Solutions, LLC; E-mail: dennisjenke{at}triadscientificsolutions.com
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    Megan Flohl, Maria Tolstyakova, Emre Seyyal, Anna Michelson, Louis Fleck, Gyorgy Vas
    ACS Omega 2025 10 20
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PDA Journal of Pharmaceutical Science and Technology: 78 (6)
PDA Journal of Pharmaceutical Science and Technology
Vol. 78, Issue 6
November/December 2024
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Correlating GC/MS Relative Response Factors to Analyte’s Physicochemical and Chromatographic Properties to Facilitate the Quantitation of Organic Extractables and Leachables in Non-Targeted Analysis (NTA). Concepts and Empirical Considerations
Dennis Jenke, Piet Christiaens, Philippe Verlinde, Jan Baeten, Jean-Marie Beusen
PDA Journal of Pharmaceutical Science and Technology Nov 2024, 78 (6) 625-642; DOI: 10.5731/pdajpst.2023.012884

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Correlating GC/MS Relative Response Factors to Analyte’s Physicochemical and Chromatographic Properties to Facilitate the Quantitation of Organic Extractables and Leachables in Non-Targeted Analysis (NTA). Concepts and Empirical Considerations
Dennis Jenke, Piet Christiaens, Philippe Verlinde, Jan Baeten, Jean-Marie Beusen
PDA Journal of Pharmaceutical Science and Technology Nov 2024, 78 (6) 625-642; DOI: 10.5731/pdajpst.2023.012884
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Keywords

  • Extractables
  • Leachables
  • Quantitation
  • Non-target analysis
  • Relative response factor
  • Uncertainty factor

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