Abstract
Water packaged in three different types of 10-ml serum vials and sealed with a butyl rubber closure was exposed to extended steam autoclave cycles and high temperature storage. The results of the tests show a reduction in pH values and an increase in a UV absorbance that is dependent on time and temperature. The final pH of the water after storage may be the result of an interaction between glass and rubber extractives.
- Received August 15, 1983.
- Accepted November 24, 1983.
- Copyright © Parenteral Drug Association. All rights reserved.
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