Abstract
A new method is described for the quantitative detection of endotoxins in large volume parenterals, based on the use of limulus amoebocyte lysate in combination with a chromogenic substrate. Inhibitory effects caused by the presence of electrolytes, can be eliminated by the use of an endotoxin-dispersion-stabilizing-agent, except in case highly concentrated salt solutions are involved.
- Received July 28, 1983.
- Accepted October 18, 1983.
- Copyright © Parenteral Drug Association. All rights reserved.
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