Abstract
Various analytical methods of determining the aluminum content of CAPD (continuous ambulatory peritoneal dialysis) solutions and associated raw materials were developed and compared. The methods include two graphite furnace atomic absorption procedures and an aluminum-lumogallion fluorescence technique that can quantitate aluminum in CAPD solution at, and in some cases below, the 1-μg/liter level with good accuracy and precision. These methods were then used to examine the possible contributions to aluminum content from all aspects of the production of CAPD solutions at Travenol Laboratories, Inc. The major source of aluminum to the low, but measurable, levels in CAPD solutions was lactic acid. With the use of USP grade or equivalent ingredients, especially a low-aluminum-content lactic acid, these solutions can be prepared with aluminum levels below 10 μg/liter.
- Received June 7, 1985.
- Accepted December 23, 1986.
- Copyright © Parenteral Drug Association. All rights reserved.
PDA members receive access to all articles published in the current year and previous volume year. Institutional subscribers received access to all content. Log in below to receive access to this article if you are either of these.
If you are neither or you are a PDA member trying to access an article outside of your membership license, then you must purchase access to this article (below). If you do not have a username or password for JPST, you will be required to create an account prior to purchasing.
Full issue PDFs are for PDA members only.
Note to pda.org users
The PDA and PDA bookstore websites (www.pda.org and www.pda.org/bookstore) are separate websites from the PDA JPST website. When you first join PDA, your initial UserID and Password are sent to HighWirePress to create your PDA JPST account. Subsequent UserrID and Password changes required at the PDA websites will not pass on to PDA JPST and vice versa. If you forget your PDA JPST UserID and/or Password, you can request help to retrieve UserID and reset Password below.