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Research ArticleResearch

Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization

Sunny R. Shah, Rajesh H. Parikh, Jayant R. Chavda and Navin R. Sheth
PDA Journal of Pharmaceutical Science and Technology May 2013, 67 (3) 201-213; DOI: https://doi.org/10.5731/pdajpst.2013.00914
Sunny R. Shah
1Bhagvanlal Kapoorchand Mody Government Pharmacy College, Rajkot, Gujarat, India;
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  • For correspondence: sunnyrshah@yahoo.com
Rajesh H. Parikh
2Ramanbhai Patel College of Pharmacy, Charusat, Changa, India; and
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Jayant R. Chavda
1Bhagvanlal Kapoorchand Mody Government Pharmacy College, Rajkot, Gujarat, India;
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Navin R. Sheth
3Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India
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Abstract

The objective of the present investigation was to develop and characterize the self-nanoemulsifying drug delivery system (SNEDDS) of glimepiride, a poorly soluble drug. Solubility of glimepiride in various vehicles was determined, and ternary phase diagrams were constructed using a suitable oil, surfactant, and cosurfactant system to find out the efficient self-emulsification system. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. Formulation optimization was carried out to optimize the droplet diameter and percent drug dissolved at 5 min. The batch prepared according to the optimized formulation showed a close agreement between observed and predicted values. Box-Behnken statistical design allowed us to understand the effect of formulation variables on the rapid dissolution of drug from SNEDDS and to optimize the formulation to obtain a rapid drug dissolution at 5 min.

LAY ABSTRACT: A self-nanoemulsifying drug delivery system of glimepiride has been design, developed, and optimized. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. The Capmul MCM–Akcrysol K 140–Transcutol system was found to be the suitable ternary system that was able to release almost 80% of drug within the first 5 min. The improved dissolution of glimepiride might improve patient compliance.

  • Glimepiride
  • Self-nanoemulsifying drug delivery system
  • Box-Behnken experimental design
  • © PDA, Inc. 2013
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PDA Journal of Pharmaceutical Science and Technology: 67 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 67, Issue 3
May/June 2013
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Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization
Sunny R. Shah, Rajesh H. Parikh, Jayant R. Chavda, Navin R. Sheth
PDA Journal of Pharmaceutical Science and Technology May 2013, 67 (3) 201-213; DOI: 10.5731/pdajpst.2013.00914

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Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization
Sunny R. Shah, Rajesh H. Parikh, Jayant R. Chavda, Navin R. Sheth
PDA Journal of Pharmaceutical Science and Technology May 2013, 67 (3) 201-213; DOI: 10.5731/pdajpst.2013.00914
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  • Article
    • Abstract
    • 1. Introduction
    • 2. Materials and Methods
    • 3. BBD Experimental Design
    • 4. Preparation of GMP-Loaded SNEDDS
    • 5. Optimization of Formulation Components
    • 6. Characterization of GMP-Loaded SNEDDS
    • 7. Results and Discussion
    • 8. Conclusions
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Keywords

  • Glimepiride
  • Self-nanoemulsifying drug delivery system
  • Box-Behnken experimental design

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