Skip to main content
  • Main menu
  • User menu
  • Search

Main menu

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
PDA Journal of Pharmaceutical Science and Technology
  • .
    • Visit PDA
    • PDA Letter
    • Technical Reports
    • news uPDATe
    • Bookstore
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
PDA Journal of Pharmaceutical Science and Technology

Advanced Search

  • Home
  • Content
    • Current Issue
    • Past Issues
    • Accepted Articles
    • Email Alerts
    • RSS
    • Terms of Use
  • About PDA JPST
    • JPST Editors and Editorial Board
    • About/Vision/Mission
    • Paper of the Year
  • Author & Reviewer Resources
    • Author Resources / Submit
    • Reviewer Resources
  • JPST Access and Subscriptions
    • PDA Members
    • Institutional Subscriptions
    • Nonmember Access
  • Support
    • Join PDA
    • Contact
    • Feedback
    • Advertising
    • CiteTrack
  • Follow pda on Twitter
  • Visit PDA on LinkedIn
  • Visit pda on Facebook
Research ArticleResearch

Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization

Sunny R. Shah, Rajesh H. Parikh, Jayant R. Chavda and Navin R. Sheth
PDA Journal of Pharmaceutical Science and Technology May 2013, 67 (3) 201-213; DOI: https://doi.org/10.5731/pdajpst.2013.00914
Sunny R. Shah
1Bhagvanlal Kapoorchand Mody Government Pharmacy College, Rajkot, Gujarat, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: sunnyrshah@yahoo.com
Rajesh H. Parikh
2Ramanbhai Patel College of Pharmacy, Charusat, Changa, India; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jayant R. Chavda
1Bhagvanlal Kapoorchand Mody Government Pharmacy College, Rajkot, Gujarat, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Navin R. Sheth
3Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. RoIkamp R.,
    2. Wernicke-Panten K.,
    3. Draeger E.
    Clinical profile of the novel sulphonylurea glimepiride. Diabetes Res. Clin. Pract. 1996, July (31 Suppl.), 33–42.
    OpenUrlGoogle Scholar
  2. 2.↵
    1. Iwata M.,
    2. Fukami T.,
    3. Kawashima D.,
    4. Sakai M.,
    5. Furuishi T.,
    6. Suzuki T.,
    7. Tomono K.,
    8. Ueda H.
    Effectiveness of mechanochemical treatment with cyclodextrins on increasing solubility of glimepiride. Pharmazie 2009, 64 (6), 390–394.
    OpenUrlPubMedGoogle Scholar
  3. 3.↵
    1. Ramon G.,
    2. Raptis S. A.,
    3. Ravella R.
    Appropriate timing of glimepiride administration in patients with type 2 diabetes millitus: a study in Mediterranean countries. Endocrine 2000, 13 (1), 117–121.
    OpenUrlPubMedGoogle Scholar
  4. 4.↵
    1. Hardman J. G.,
    2. Limbird L.E.
    Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas, 10th ed.; Hardman J. G., Limbird L.E., Eds.; McGraw Hill: New York, 2001.
    Google Scholar
  5. 5.↵
    1. Seedher N.,
    2. Kanojia M.
    Micellar solubilization of some poorly soluble antidiabetic drugs: a technical note. AAPS PharmSciTech 2008, 9 (2), 431–436.
    OpenUrlPubMedGoogle Scholar
  6. 6.↵
    1. Seedher N.,
    2. Kanojia M.
    Co-solvent solubilization of some poorly-soluble antidiabetic drugs. Pharm. Dev. Technol. 2009, 14 (2), 185–192.
    OpenUrlPubMedGoogle Scholar
  7. 7.↵
    1. Ning X.,
    2. Sun J.,
    3. Han X.,
    4. Wu Y.,
    5. Yan Z.,
    6. Han J.,
    7. He Z.
    Strategies to improve dissolution and oral absorption of glimepiride tablets: solid dispersion versus micronization techniques. Drug Dev. Ind. Pharm. 2011, 37 (6), 727–736.
    OpenUrlPubMedGoogle Scholar
  8. 8.↵
    1. Ammar H. O.,
    2. Salama H. A.,
    3. Ghorab M.,
    4. Mahmoud A. A.
    Implication of inclusion complexation of glimepiride in cyclodextrin–polymer systems on its dissolution, stability and therapeutic efficacy. Int. J. Pharm. 2006, 320 (1-2) 53–57.
    OpenUrlPubMedGoogle Scholar
  9. 9.↵
    1. Taha E. I.,
    2. Al-Suwayeh S. A.,
    3. Anwer M. K.
    Preparation, in vitro and in vivo evaluation of solid-state self-nanoemulsifying drug delivery system (SNEDDS) of vitamin A acetate. J. Drug Target. 2009, 17 (6), 468–673.
    OpenUrlPubMedGoogle Scholar
  10. 10.↵
    1. Anton N.,
    2. Vandamme T. F.
    Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm. Res. 2010, 28 (5), 978–985.
    OpenUrlPubMedGoogle Scholar
  11. 11.↵
    1. Grbic S.,
    2. Parojcic J.,
    3. Malenovic A.,
    4. Djuric Z.,
    5. Maksimovic M.
    A contribution to the glimepiride dissociation constant determination. J. Chem. Eng. Data 2010, 55 (3), 1368–1371.
    OpenUrlGoogle Scholar
  12. 12.↵
    1. Date A. A.,
    2. Nagarsenker M. S.
    Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int. J. Pharm. 2007, 329 (1-2), 166–172.
    OpenUrlPubMedGoogle Scholar
  13. 13.↵
    1. Brüsewitz C.,
    2. Schendler A.,
    3. Funke A.,
    4. Wagner T.,
    5. Lipp R.
    Novel poloxamer-based nanoemulsions to enhance the intestinal absorption of active compounds. Int. J. Pharm. 2007, 329 (1-2), 173–181.
    OpenUrlPubMedGoogle Scholar
  14. 14.↵
    1. Dabhi M. R.,
    2. Limbani M. D.,
    3. Sheth N. R.
    Preparation and in vivo evaluation of self-nanoemulsifying drug delivery system (SNEDDS) containing ezetimibe. Curr. Nanosci. 2011, 7 (4), 616–627.
    OpenUrlGoogle Scholar
  15. 15.↵
    U.S. Food and Drug Administration (USFDA). USFDA Guidelines (Cited January 13, 2009). Available from http://www.accessdata.fda.gov/scripts/cder/dissolution/dsp_SearchResults_Dissolutions.cfm.
    Google Scholar
  16. 16.↵
    1. Li W.,
    2. Yi S.,
    3. Wang Z.,
    4. Chen S.,
    5. Xin S.,
    6. Xie J.,
    7. Zhao C.
    Self-nanoemulsifying drug delivery system of persimmon leaf extract: optimization and bioavailability studies. Int. J. Pharm. 2011, 420 (1), 161–171.
    OpenUrlPubMedGoogle Scholar
  17. 17.↵
    1. Zhu S.,
    2. Hong M.,
    3. Liu C.,
    4. Pei Y.
    Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation. Pharm. Dev. Technol. 2009, 14 (6) 642–649.
    OpenUrlPubMedGoogle Scholar
  18. 18.↵
    1. Ivanova R.,
    2. Lindman B.,
    3. Alexandridis P.
    Effect of glycols on the selfassembly of amphiphilic block copolymers in water. 1. Phase diagrams and structure identification. Langmuir 2000, 16 (8), 3660–3675.
    OpenUrlGoogle Scholar
  19. 19.↵
    1. Taha E. I.,
    2. Al-Saidan S.,
    3. Samy A. M.,
    4. Khan M. A.
    Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Int. J. Pharm. 2004, 285 (102), 109–119.
    OpenUrlPubMedGoogle Scholar
PreviousNext
Back to top

In This Issue

PDA Journal of Pharmaceutical Science and Technology: 67 (3)
PDA Journal of Pharmaceutical Science and Technology
Vol. 67, Issue 3
May/June 2013
  • Table of Contents
  • Index by Author
Print
Download PDF
Article Alerts
Email Article
Citation Tools
Share
Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization
Sunny R. Shah, Rajesh H. Parikh, Jayant R. Chavda, Navin R. Sheth
PDA Journal of Pharmaceutical Science and Technology May 2013, 67 (3) 201-213; DOI: 10.5731/pdajpst.2013.00914
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget

Jump to section

  • Article
    • Abstract
    • 1. Introduction
    • 2. Materials and Methods
    • 3. BBD Experimental Design
    • 4. Preparation of GMP-Loaded SNEDDS
    • 5. Optimization of Formulation Components
    • 6. Characterization of GMP-Loaded SNEDDS
    • 7. Results and Discussion
    • 8. Conclusions
    • Conflict of Interest Declaration
    • Acknowledgements
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Nitrogen Dioxide sterilization follows log-linear microbial inactivation kinetics using Geobacillus stearothermophilus biological indicators
  • Worldwide Regulatory Reliance: Results of an Executed Chemistry, Manufacturing, and Control Post-Approval Change Pilot
  • Preservative Efficacy Testing of Refrigerated Pharmaceuticals: Choice of Challenging Isolate and Storage Temperature
Show more Research

Similar Articles

Keywords

  • Glimepiride
  • Self-nanoemulsifying drug delivery system
  • Box-Behnken experimental design

Readers

  • About
  • Table of Content Alerts/Other Alerts
  • Subscriptions
  • Terms of Use
  • Contact Editors

Author/Reviewer Information

  • Author Resources
  • Submit Manuscript
  • Reviewers
  • Contact Editors

Parenteral Drug Association, Inc.

  • About
  • Advertising/Sponsorships
  • Events
  • PDA Bookstore
  • Press Releases

© 2025 PDA Journal of Pharmaceutical Science and Technology Print ISSN: 1079-7440  Digital ISSN: 1948-2124

Powered by HighWire
Alerts for this Article
Sign In to Email Alerts with your Email Address
Email this Article

Thank you for your interest in spreading the word on PDA Journal of Pharmaceutical Science and Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization
(Your Name) has sent you a message from PDA Journal of Pharmaceutical Science and Technology
(Your Name) thought you would like to see the PDA Journal of Pharmaceutical Science and Technology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
4 + 4 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization
Sunny R. Shah, Rajesh H. Parikh, Jayant R. Chavda, Navin R. Sheth
PDA Journal of Pharmaceutical Science and Technology May 2013, 67 (3) 201-213; DOI: 10.5731/pdajpst.2013.00914

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

We use cookies on this site to enhance your user experience

By clicking any link on this page you are giving your consent for us to set cookies.