Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures

Qingyu Zeng; Anthony Bucci; Le Ho

doi:10.5731/pdajpst.2019.010371

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Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures

Qingyu Zeng, Anthony Bucci and Le Ho

PDA Journal of Pharmaceutical Science and Technology January 2020, 74 (1) 27-40; DOI: https://doi.org/10.5731/pdajpst.2019.010371

Qingyu Zeng

West Pharmaceutical Services, Inc, Exton, PA 19341

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For correspondence: qingyu.zeng@westpharma.com

Anthony Bucci

West Pharmaceutical Services, Inc, Exton, PA 19341

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Le Ho

West Pharmaceutical Services, Inc, Exton, PA 19341

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vol. 74 no. 1 27-40

DOI

https://doi.org/10.5731/pdajpst.2019.010371

PubMed

31308066

Published By

Parenteral Drug Association (PDA)

Print ISSN

1079-7440

Online ISSN

1948-2124

History

Published online February 3, 2020.

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previous version (July 15, 2019 - 09:03).
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Qingyu Zeng*,
Anthony Bucci and
Le Ho

West Pharmaceutical Services, Inc, Exton, PA 19341

↵* Corresponding Author: West Pharmaceutical Services, Inc., 530 Herman O. West Drive, Exton, PA 19341; e-mail: qingyu.zeng{at}westpharma.com

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Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures

Qingyu Zeng, Anthony Bucci, Le Ho

PDA Journal of Pharmaceutical Science and Technology Jan 2020, 74 (1) 27-40; DOI: 10.5731/pdajpst.2019.010371

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Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures

Qingyu Zeng, Anthony Bucci, Le Ho

PDA Journal of Pharmaceutical Science and Technology Jan 2020, 74 (1) 27-40; DOI: 10.5731/pdajpst.2019.010371

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Keywords

Compression stress relaxation (CSR)
Residual seal force (RSF)
Container closure system (CCS)
Container closure integrity (CCI)
Stopper
Vial
Cap
Seal
Capping
Time-dependent
Temperature-dependent
Maxwell–Wiechert model
Kohlrausch–Williams–Watts (KWW) stretched exponential function
Time–temperature superposition
Arrhenius
Williams–Landel–Ferry (WLF)

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Time Temperature Superposition Evaluation and Modeling for Container Closure System's Seal Performance at Low Temperatures

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